TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Liver carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5030719
rs5030719
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE (1) rs5030719 was monomorphic and was not further analysed; (2) the rs2149356 T allele carrier state was significantly less frequent in patients with HCC than in healthy controls (OR 0.421, 95% CI 0.285-0.625) and in patients with chronic hepatitis C (OR 0.426, 95% CI 0.236-0.767); (3) the proportion of rs2149356 T allele carriers progressively diminished with increasing clinical stage of HCC; (4) no significant differences were observed for the rs4986791 T allele. 22286521 2012