TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)). 18434886 2008
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE The minor allele frequency of rs1800629 was significantly higher in severe sepsis patients than that in both healthy controls (P(adj) = 0.00046, odds ratio (OR)(adj) = 1.92) and sepsis patients (P(adj) = 0.002, OR(adj) = 1.56). 23029405 2012
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis. 26025100 2015
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10. 27592234 2016
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population. 29340067 2017