TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0033860
Disease:
Psoriasis
0.010 GeneticVariation BEFREE Haplotype analysis suggests that the coexistence of the polymorphisms rs1799964 (TNF-α), rs2010963 (VEGF), rs833061 (VEGF), and rs6311 (5HT2A) may be a protective factor for psoriasis. 31148856 2020
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C4721555
Disease:
Autoimmune hepatitis
0.010 GeneticVariation BEFREE Association of <i>CARD10</i> rs6000782 and <i>TNF</i> rs1799724 variants with paediatric-onset autoimmune hepatitis. 30581618 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0017601
Disease:
Glaucoma
0.010 GeneticVariation BEFREE Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort. 31132515 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE In addition, TNF rs1799724 and rs1800629 were associated with TB, but only in the Tibetan population. 30792445 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE Association of <i>CARD10</i> rs6000782 and <i>TNF</i> rs1799724 variants with paediatric-onset autoimmune hepatitis. 30581618 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0003872
Disease:
Arthritis, Psoriatic
0.010 GeneticVariation BEFREE The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026). 30584776 2019
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0025958
Disease:
Microcephaly
0.010 GeneticVariation BEFREE Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13-6.21). 31352487 2019
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0376620
Disease:
Pouchitis
0.010 GeneticVariation BEFREE SNP genotyping was performed for 8 SNPs reportedly associated with UCAC and pouchitis, namely: ELF1 (rs7329174), FCGR2A, (rs1801274), interleukin-1β (IL-1B; rs1143627), ITLN1 (rs2274910), MHC (rs7765379), TNFα (rs1799964), TNFSF15 (rs3810936), and UHMK1 (rs768910), using TaqMan genotyping technologies. 31671425 2019
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C4552332
Disease:
Congenital Zika syndrome
0.010 GeneticVariation BEFREE Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13-6.21). 31352487 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females. 30967802 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0035222
Disease:
Respiratory Distress Syndrome, Adult
0.010 GeneticVariation BEFREE The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively). 31261506 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0017601
Disease:
Glaucoma
0.010 GeneticVariation BEFREE Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort. 31132515 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females. 30967802 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1623038
Disease:
Cirrhosis
0.010 GeneticVariation BEFREE TNF-α rs1800629 polymorphism is a potential genetic-susceptibility factor for HCV related cirrhosis and HCC progression. 30204505 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0242383
Disease:
Age related macular degeneration
0.010 GeneticVariation BEFREE To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD. 30662836 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease:
Acquired Immunodeficiency Syndrome
0.010 GeneticVariation BEFREE The association with A-G-A-C haplotype (beta = 0.718; standard error = 0.182; P = 0.0002) and with other 8.1AH-specific haplotypes including the high-producing tumor necrosis factor-alpha haplotype rs909253(G)-rs1800629(A) (beta = 0.308; standard error = 0.140; P = 0.032) were observed only with NHL identified as an AIDS-defining condition, but not as a post-AIDS condition, nor in combined AIDS and post-AIDS cases. 31026237 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
0.010 GeneticVariation BEFREE We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML. 31373163 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001339
Disease:
Acute pancreatitis
0.010 GeneticVariation BEFREE Epistasis analysis revealed that AP susceptibility was increased by interaction between <i>IL23R</i> rs11209026 and <i>TNF</i> rs1800629 (p = 1.205 × 10<sup>-5</sup>; OR<sub>interaction</sub> = 4.031). 31044631 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0023890
Disease:
Liver Cirrhosis
0.010 GeneticVariation BEFREE TNF-α rs1800629 polymorphism is a potential genetic-susceptibility factor for HCV related cirrhosis and HCC progression. 30204505 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0022104
Disease:
Irritable Bowel Syndrome
0.010 GeneticVariation BEFREE No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. 31615448 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0014057
Disease:
Japanese Encephalitis
0.010 GeneticVariation BEFREE TNFA rs1800629 A and CCR5 rs1799987 A alleles were associated with susceptibility while combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, and rs1799987 A alleles and CCL2 rs1024611 G/G genotype was associated with protection to JE. 31479868 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females. 30967802 2019
dbSNP: rs1800630
rs1800630
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0017601
Disease:
Glaucoma
0.010 GeneticVariation BEFREE Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort. 31132515 2019
dbSNP: rs1800630
rs1800630
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE Moreover, TNF rs1799964 and rs1800630 were risk factors for susceptibility to TB, which were validated in the Chinese Tibetan population. 30792445 2019
dbSNP: rs1800630
rs1800630
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0242383
Disease:
Age related macular degeneration
0.010 GeneticVariation BEFREE To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD. 30662836 2019