TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3093668
rs3093668
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836232
Disease:
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs3093668
rs3093668
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836230
Disease:
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs3093668
rs3093668
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs3093662
rs3093662
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.700 GeneticVariation GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C4016417
Disease:
VASCULAR DEMENTIA, SUSCEPTIBILITY TO
T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C1856170
Disease:
ALZHEIMER DISEASE, SUSCEPTIBILITY TO
T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs281865419
rs281865419
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4016415
Disease:
TNF RECEPTOR BINDING, ALTERED
T 0.700 CausalMutation CLINVAR
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). 30916218 2019
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525), and TNFR1 -609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients. 29404828 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE This study identifies a potentially important role for TNF-α rs1800629 polymorphisms in the susceptibility to RA.However, further studies in larger cohorts are required. 25263964 2014
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE TNF-α rs1800629 A/G, NLRP1 rs878329 C/G and NLRP1 rs6502867 C/T polymorphisms were not associated with risk of RA or AS. 24065540 2013
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE A long-term observational early RA inception cohort (n = 208) with detailed information about disease activity and radiologic damage after 3, 6 and 9 years of disease was genotyped for the TNFA -308G > A promoter polymorphism (rs1800629). 23217265 2012
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. 22927710 2012
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.070 GeneticVariation BEFREE Our results show that TNFA rs1800629 gene polymorphism is associated with predisposition to CV complications in patients with RA. 21420089 2011
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). 25713336 2015
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. 22649007 2012
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87). 20087644 2010
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253 A>G) and tumor necrosis factor (TNF -308A, rs1800629 G>A), form the G-A haplotype repeatedly associated with increased risk of non-Hodgkin lymphoma (NHL) in individuals uninfected with HIV-1. 19654554 2009
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE Compared with the wild-type (GG), the AA genotype for the TNF promoter polymorphism G-308A (rs1800629) was associated with increased risk of NHL [odds ratio (OR), 2.14; 95% confidence interval (95% CI), 0.94-4.85], whereas the GA genotype was not (OR, 1.00; 95% CI, 0.74-1.34). 18990758 2008
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.060 GeneticVariation BEFREE Two common single nucleotide polymorphisms in immunoregulatory genes (TNF G308A, rs1800629 and IL10 T3575A, rs1800890) have been recently reported as risk factors for non-Hodgkin lymphoma (NHL) in a large pooled analysis. 17510437 2007
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007847
Disease:
Malignant tumor of cervix
0.050 GeneticVariation BEFREE The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer. 29940817 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4048328
Disease:
cervical cancer
0.050 GeneticVariation BEFREE The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer. 29940817 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0302592
Disease:
Cervix carcinoma
0.050 GeneticVariation BEFREE The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer. 29940817 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036690
Disease:
Septicemia
0.050 GeneticVariation BEFREE Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population. 29340067 2017
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007847
Disease:
Malignant tumor of cervix
0.050 GeneticVariation BEFREE Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-?) promoter region at positions -308G>A (rs1800629) and -238G>A (rs361525) to cervical cancer risk have been inconclusive. 27039819 2016