TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800630
rs1800630
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0031106
Disease:
Aggressive Periodontitis 		0.010 GeneticVariation BEFREE A meta-analysis was performed to assess the effect of TNF-α -308G/A (rs1800629), -238G/A (rs361525) and -863C/A (rs1800630) polymorphisms on either chronic (CP) or aggressive periodontitis (AgP) risk. 24905365 2014
dbSNP: rs361525
rs361525
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0031106
Disease:
Aggressive Periodontitis 		0.010 GeneticVariation BEFREE A meta-analysis was performed to assess the effect of TNF-α -308G/A (rs1800629), -238G/A (rs361525) and -863C/A (rs1800630) polymorphisms on either chronic (CP) or aggressive periodontitis (AgP) risk. 24905365 2014
dbSNP: rs3093661
rs3093661
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs3093661
rs3093661
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASDB The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. 21051598 2010
dbSNP: rs3093662
rs3093662
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASDB The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. 21051598 2010
dbSNP: rs3093662
rs3093662
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs3093668
rs3093668
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C2607914
Disease:
Allergic rhinitis (disorder) 		0.020 GeneticVariation BEFREE Children carrying a minor rs1800629 (TNF) or rs1927911 (TLR4) allele may be at a higher risk of allergic rhinitis. 23639307 2013
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C2607914
Disease:
Allergic rhinitis (disorder) 		0.020 GeneticVariation BEFREE In TNFA, a significant relationship was also detected between rs1800629 and rs361525 and allergic rhinitis. 24654309 2013
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C2607914
Disease:
Allergic rhinitis (disorder) 		0.010 GeneticVariation BEFREE TNF-α SNP rs1799964 and MRPL4 SNP rs11668618 were found to occur in significantly greater frequencies in the AR group compared to control group. 23472126 2013
dbSNP: rs361525
rs361525
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C2607914
Disease:
Allergic rhinitis (disorder) 		0.010 GeneticVariation BEFREE In TNFA, a significant relationship was also detected between rs1800629 and rs361525 and allergic rhinitis. 24654309 2013
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C1856170
Disease:
ALZHEIMER DISEASE, SUSCEPTIBILITY TO 		T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0002395
Disease:
Alzheimer's Disease 		0.020 GeneticVariation BEFREE A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor α (TNF). 20693638 2010
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0002395
Disease:
Alzheimer's Disease 		0.020 GeneticVariation BEFREE Haplotyping analysis revealed a significant overrepresentation of an rs1799724-T/rs1800629-G haplotype in AD (P=0.012; OR, 1.60; 95% CI, 1.11-2.29), although to a lesser degree than rs1799724-T alone. 15895461 2005
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0002395
Disease:
Alzheimer's Disease 		0.010 GeneticVariation BEFREE Haplotyping analysis revealed a significant overrepresentation of an rs1799724-T/rs1800629-G haplotype in AD (P=0.012; OR, 1.60; 95% CI, 1.11-2.29), although to a lesser degree than rs1799724-T alone. 15895461 2005
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.030 GeneticVariation BEFREE For rs1800629, the A allele was also linked to reduced risk of AS (p < 0.0001, OR = 0.54, 95% CI = 0.39-0.74). 29230494 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.030 GeneticVariation BEFREE While <i>TNF</i>-308 (rs1800629) AA/GA, <i>IL17A</i> (rs2275913) AA/GA, and <i>IL17F</i> (rs763780) CC/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of <i>HLA-B27</i>, <i>TNF</i>-238 (rs361525) GA/AA, <i>IL17A</i> (rs2275913) AA/GA, and <i>IL17F</i> (rs763780) genotypes was associated with PsA. 29849482 2018
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.030 GeneticVariation BEFREE We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026). 30208882 2018
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.010 GeneticVariation BEFREE For rs1799964, the C allele was linked to reduced risk of AS (p < 0.0001, OR = 0.60, 95% CI = 0.50-0.71). 29230494 2018
dbSNP: rs1800630
rs1800630
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.010 GeneticVariation BEFREE For rs1800630, the A allele was also linked to reduced risk of AS (p < 0.0001, OR = 0.59, 95% CI = 0.48-0.72). 29230494 2018
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0003467
Disease:
Anxiety 		0.010 GeneticVariation BEFREE Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. 25813148 2016
dbSNP: rs3093662
rs3093662
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003467
Disease:
Anxiety 		0.010 GeneticVariation BEFREE Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. 25813148 2016
dbSNP: rs1799964
rs1799964
Entrez Id: 4049;7124;100287329
Gene Symbol: LTA;TNF;LOC100287329
LTA;TNF;LOC100287329
CUI: C0003469
Disease:
Anxiety Disorders 		0.010 GeneticVariation BEFREE Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. 25813148 2016
dbSNP: rs3093662
rs3093662
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003469
Disease:
Anxiety Disorders 		0.010 GeneticVariation BEFREE Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. 25813148 2016
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003850
Disease:
Arteriosclerosis 		0.010 GeneticVariation BEFREE To assess the influence of the TNFA rs1800629 (G > A) polymorphism in the risk of cardiovascular (CV) disease and subclinical atherosclerosis in patients with rheumatoid arthritis (RA). 21420089 2011