TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 genotypes on the association of any of the remaining polymorphisms with lung cancer risk was also examined. 24139238 2014
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0392077
Disease:
Cardiac sarcoidosis
0.010 GeneticVariation BEFREE We concluded that the rs1799724 C/T polymorphism may affect susceptibility to cardiac sarcoidosis, while the rs1800871 T/C and rs1800872A/C polymorphisms may affect susceptibility to sarcoidosis with eye involvement. 24003533 2013
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0024535
Disease:
Malaria, Falciparum
0.010 GeneticVariation BEFREE We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. 17493155 2007
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0524909
Disease:
Hepatitis B, Chronic
0.010 GeneticVariation BEFREE To test this hypothesis, we investigated the role of TNF-α polymorphism [-863C/A (rs1800630), -308G/A (rs1800629), -376G/A (rs1800750), -857C/T (rs1799724) and +489G/A (rs1800610)] in the susceptibility to chronic hepatitis B (CHB) infection. 29054398 2017
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE The study demonstrated -857C/T (rs1799724) polymorphism may not have influenced RA susceptibility in our study group. 27126784 2016
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C4721555
Disease:
Autoimmune hepatitis
0.010 GeneticVariation BEFREE Association of <i>CARD10</i> rs6000782 and <i>TNF</i> rs1799724 variants with paediatric-onset autoimmune hepatitis. 30581618 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0017601
Disease:
Glaucoma
0.010 GeneticVariation BEFREE Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort. 31132515 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE In this study we genotyped four common single nucleotide polymorphisms (SNPs) in the TNF-α promoter [ -308G > A(rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964)] and determined HPV16 serology in 325 OSCC cases and 335 matched controls and tumor HPV status in 176 squamous cell carcinomas of the oropharynx (SCCOP) patients. 23870134 2013
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0007847
Disease:
Malignant tumor of cervix
0.010 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0859976
Disease:
Idiopathic achalasia of esophagus
0.010 GeneticVariation BEFREE Our study provides evidence for rs1799724 at the LTA/TNFα locus as a susceptibility factor for idiopathic achalasia. 24259423 2014
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C1321756
Disease:
Achalasia
0.010 GeneticVariation BEFREE SNPs in high LD with rs1799724 were associated with achalasia. 24259423 2014
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0014848
Disease:
Esophageal Achalasia
0.010 GeneticVariation BEFREE SNPs in high LD with rs1799724 were associated with achalasia. 24259423 2014
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE The aim of this study was to test whether rs1799724, an SNP of TNF-α, contributes to the neuroanatomical changes in MDD. 30310056 2018
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0036202
Disease:
Sarcoidosis
0.010 GeneticVariation BEFREE We concluded that the rs1799724 C/T polymorphism may affect susceptibility to cardiac sarcoidosis, while the rs1800871 T/C and rs1800872A/C polymorphisms may affect susceptibility to sarcoidosis with eye involvement. 24003533 2013
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE In addition, TNF rs1799724 and rs1800629 were associated with TB, but only in the Tibetan population. 30792445 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE Lack of TNF-α Gene Polymorphism (rs1799724) Association with Sustained Virological Response in Iranian Patients with Chronic HCV Infection. 27644640 2016
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C4048328
Disease:
cervical cancer
0.010 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE Association of <i>CARD10</i> rs6000782 and <i>TNF</i> rs1799724 variants with paediatric-onset autoimmune hepatitis. 30581618 2019
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C2747816
Disease:
Complicated malaria
0.010 GeneticVariation BEFREE We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. 17493155 2007
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE Since growing evidences suggest the crucial and complex role of the tumor necrosis factor in the CNS, we have hypothesized that functional genetic variants of the LTA and TNFA genes (LTA +252A/G (rs909253) and TNFA -857C/T (rs1799724) and TNFA -238G/A (rs361525)) may be involved in the predisposition to schizophrenia. 30627222 2018
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0010346
Disease:
Crohn Disease
0.010 GeneticVariation BEFREE We found that the TNF-α rs1799724 C>T polymorphism increased the susceptibility to CD (allele model: OR = 1.293, 95%CI = 1.090-1.534, P = 0.003; dominant model: OR = 1.258, 95%CI = 1.031-1.534, P = 0.024). 26634549 2015
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0497327
Disease:
Dementia
0.010 GeneticVariation BEFREE After a 5-year follow-up, the elderly carriers of T-allele of TNF-α rs1799724 were at an increased risk of dementia (p = 0.03). 21509504 2012
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0023343
Disease:
Leprosy
0.010 GeneticVariation BEFREE In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. 25636570 2015
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0302592
Disease:
Cervix carcinoma
0.010 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015
dbSNP: rs1799724
rs1799724
Entrez Id: 4049;7124
Gene Symbol: LTA;TNF
LTA;TNF
CUI: C0003872
Disease:
Arthritis, Psoriatic
0.010 GeneticVariation BEFREE The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026). 30584776 2019