TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Endothelial dysfunction ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800629
rs1800629
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0856169
Disease:
Endothelial dysfunction 		0.010 GeneticVariation BEFREE In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. 22927710 2012