rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
BEFREE
Patient 1 with LFS and TP53(R273H ) developed a rhabdomyosarcoma twice at the ages of 18 months and 21 years.
21484931
2011
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
24493721
2014
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
American Society of Clinical Oncology policy statement update: genetic and genomic testing for cancer susceptibility.
20065170
2010
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
1565144
1992
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
A germline missense mutation R337C in exon 10 of the human p53 gene.
9452042
1998
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
G
0.820
CausalMutation
CLINVAR
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.
9242456
1997
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
A
0.820
CausalMutation
CLINVAR
P53 germline mutations in childhood cancers and cancer risk for carrier individuals.
10864200
2000
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
Gastric cancer in individuals with Li-Fraumeni syndrome.
21552135
2011
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome.
17540308
2007
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
10484981
1999
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
BEFREE
Here we report on a child with Li-Fraumeni syndrome with a de novo TP53 mutation c.818G>A , who developed three malignancies at the age of 4 months, 4 and 5 years, respectively.
25787918
2015
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.
25394175
2015
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
Sebaceous gland carcinoma of the eyelid masquerading as a cutaneous horn in Li--Fraumeni syndrome.
20693561
2011
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
1565144
1992
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
The tumor suppressor p53: from structures to drug discovery.
20516128
2010
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
A
0.820
CausalMutation
CLINVAR
Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers.
26014290
2015
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
2259385
1991
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
Mutants TP53 p.R273H and p.R273C but not p.R273G enhance cancer cell malignancy.
24677579
2014
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
7887414
1995
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
P53 germline mutations in childhood cancers and cancer risk for carrier individuals.
10864200
2000
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
T
0.820
CausalMutation
CLINVAR
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells.
17636407
2007
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.
17392385
2007
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
1737852
1992
rs28934576
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Li-Fraumeni Syndrome
0.820
GeneticVariation
UNIPROT
Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors.
15604628
2004