TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934575
rs28934575
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
T 0.700 GeneticVariation CLINVAR
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas. 26855149 2016
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE Using genetically engineered mouse models, we show that heterozygous mutation of Dpc4/Smad4 attenuates the metastatic potential of Kras(G12D/+);Trp53(R172H/+) pancreatic ductal adenocarcinomas while increasing their proliferation. 26004068 2015
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE Mice with pancreas-specific tsTAg expression developed acinar cell dysplasia by 22 weeks without PanIN formation, while mice expressing both tsTAg and Kras(G12D) developed highly aggressive adenocarcinoma with a ductal cell phenotype within a short period, and died within 3 weeks. 25042889 2014
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes. 24858378 2014
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE Loss of Pten in the Kras(G12D);Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. 22396451 2012
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression. 23019409 2012
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE TVA-mediated infection of genetically engineered mice with endogenous expression of Kras(G12D) in pancreatic progenitor cells by using RCASBP(A) virus carrying a short hairpin RNA directed against murine TP53, resulted in dramatically enhanced progression to invasive adenocarcinomas. 18621715 2008
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.080 GeneticVariation BEFREE We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas. 17349581 2007
dbSNP: rs754332870
rs754332870
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE Analysis of the KRAS gene showed only a G12C variation in one large cell carcinoma (LCC) patient, whereas variants were not found in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) cases. 30048458 2018
dbSNP: rs1131691021
rs1131691021
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas. 26855149 2016
dbSNP: rs754332870
rs754332870
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE Seven of 17 cases (41%) were reclassified in the adenocarcinoma with solid pattern group, which showed one KRAS G12C and one EGFR E709K + G719C double mutation in addition to mutations in TP53. 26430808 2016
dbSNP: rs1131691021
rs1131691021
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes. 24858378 2014
dbSNP: rs1800372
rs1800372
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE In addition, we detected the rare R213R (rs1800372, minor allele frequency: 0.0054) polymorphism in 7.2% of the patients and are the first to show the significant association with TP53 mutations in non-small cell lung cancer adenocarcinoma patients (p = 0.003). 28240049 2017
dbSNP: rs1057519747
rs1057519747
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas. 18234966 2008
dbSNP: rs121912665
rs121912665
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas. 18234966 2008
dbSNP: rs587782289
rs587782289
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE An SNP, Thr706Ala, in the POLI gene encoding another translesion DNA polymerase was associated with adenocarcinoma and squamous cell carcinoma risk, particularly in individuals of ages < 61 years (OR Ala/Ala + Ala/Thr vs. Thr/Thr = 1.5 and 2.4, respectively). 15609317 2005
dbSNP: rs967461896
rs967461896
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE One eccrine gland adenocarcinoma showed allelic loss of 17p and a Cys 176 Arg mutation in the p53 gene. 10660129 2000