TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk. 31759353 2019
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE TP53 Arg72Pro (rs1042522 C > G) and miR-34b/c rs4938723 (T > C) polymorphisms have been known to modify cancer susceptibility. 31325764 2019
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. 30519324 2018
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms' tumor. 28260929 2017
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Risk of cancer</span> specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered. 28336930 2017
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the p53 R72P polymorphism. 28594296 2017
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Hence, this study explores the single and combined effects of cancer risk, age of onset and cancer type of three single nucleotide polymorphisms (SNPs)-TP53 Pro72Arg, MDM2 SNP285 and SNP309-already described as modifiers on TP53 mutation carriers but not properly investigated in LFS Suggestive patients. 26956143 2016
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. 26619844 2016
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on thyroid cancer risk. 25835179 2015
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. 25768405 2015
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis. 26320432 2015
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE TP53 Arg72Pro polymorphism has been proposed to have some effects on host's susceptibility to cancer. 24375191 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Mouse models for the p53 R72P polymorphism have recently been developed but a role for this SNP in modifying cancer risk in response to viral and chemical carcinogens has yet to be established experimentally. 23475592 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy. 25605158 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE We have also found that the ectopic expression of p53-R248W/P72R in MG63 cells promoted cancer stem-like features, as high proliferation rate, sphere formation, clonogenic growth, high migration and invasive ability; furthermore, it strongly increased the levels of stemness proteins. 24373920 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE TP53 P72R polymorphism significantly contributes to increased African American cancer disparity. 24743655 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg). 24935583 2014
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE p53 gene variants i.e.16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. 23621193 2013
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in different cancers including breast cancer. 21365326 2012
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Thus, it is evident from our study that Arg72Pro SNP is implicated in kangri cancer and that the rare, proline-related allele is connected with higher susceptibility to kangri cancer. 22249977 2012
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR. 23053979 2012
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism. 21976716 2012
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility. 20886596 2011
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. 21468597 2011
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The p53 Arg72Pro single-nucleotide polymorphism (SNP) was found to be associated with an increased risk of various malignancies. 21778786 2011