TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Breast Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1064795369
rs1064795369
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE We conclude that the Ex4 + 119G > C TP53 polymorphism is an independent, low penetrance marker of BC risk in this population. 23716179 2013
dbSNP: rs1064795369
rs1064795369
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE We evaluated whether three well-characterized TP53 variants -- Ex4 + 119 C > G (rs#1042522, Arg72Pro), IVS6 + 62 A > G (rs#1625895), and an IVS3 16 bp insertion/ deletion (INDEL; rs#17878362) -- were associated with breast cancer risk in a population-based case-control study. 17624591 2008
dbSNP: rs1064795369
rs1064795369
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE The tightly linked intronic ATM polymorphisms IVS22-77 T>C and IVS48 + 238 C>G, in the homozygote state were associated with increased BC risk [IVS22-77 CC versus TT odds ratio (OR), 1.67; 95% confidence interval (CI), 1.00-2.81], and in the heterozygote state with clinical radioprotection (IVS22-77 CT versus TT OR, 0.45; 95% CI, 0.24-0.85). 14695186 2003