TPO, thyroid peroxidase, 7173

N. diseases: 306; N. variants: 47
Disease: Graves Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11675434
rs11675434
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0018213
Disease:
Graves Disease 		0.020 GeneticVariation BEFREE We found that the T allele of rs11675434 was significantly more frequent in GD patients with than without GO (odds ratio (OR)=1.26, 95% confidence interval (CI)=1.05-1.51, P=0.012), which was consistent with our previous findings. 27829681 2017
dbSNP: rs11675434
rs11675434
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0018213
Disease:
Graves Disease 		0.020 GeneticVariation BEFREE Although rs11675434 located near TPO showed no association with GD susceptibility, it was significantly associated with the presence of clinically evident Graves' ophthalmopathy (GO, P = 5·2 × 10(-5) , OR = 1·64), and this effect was independent from smoking status, age of GD onset and gender. 25345847 2015