Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7832552
rs7832552
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0424678
Disease:
Lean body mass
T 0.800 GeneticVariation GWASDB Subjects carrying unfavorable genotypes at rs16892496 and rs7832552 had, on average, 2.70 and 2.55 kg lower LBM, respectively, compared to those with alternative genotypes. 19268274 2009
dbSNP: rs7832552
rs7832552
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0424678
Disease:
Lean body mass
T 0.800 GeneticVariation GWASCAT Subjects carrying unfavorable genotypes at rs16892496 and rs7832552 had, on average, 2.70 and 2.55 kg lower LBM, respectively, compared to those with alternative genotypes. 19268274 2009
dbSNP: rs12544197
rs12544197
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0023508
Disease:
White Blood Cell Count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs16892496
rs16892496
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0424678
Disease:
Lean body mass
0.700 GeneticVariation GWASDB Subjects carrying unfavorable genotypes at rs16892496 and rs7832552 had, on average, 2.70 and 2.55 kg lower LBM, respectively, compared to those with alternative genotypes. 19268274 2009
dbSNP: rs16892496
rs16892496
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME. 28294290 2017
dbSNP: rs771222349
rs771222349
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
CUI: C0020676
Disease:
Hypothyroidism
0.010 GeneticVariation BEFREE A homozygous missense mutation in TRHR (c.392T > C; p.I131T) was identified in an 8-year-old boy with moderate hypothyroidism (TSH: 2.61 mIU/L, Normal: 0.27 to 4.2; free thyroxine: 9.52 pmol/L, Normal: 10.9 to 25.7) who was overweight (body mass index: 20.4 kg/m2, p91) but had normal stature (122 cm; -0.58 standard deviation). 28419241 2017