TYK2, tyrosine kinase 2, 7297

N. diseases: 172; N. variants: 22
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.830 GeneticVariation BEFREE Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis. 30899276 2019
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		G 0.830 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114 2019
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.830 GeneticVariation BEFREE Genetic overlap between PsA and RA was detected for the rs34536443 SNP of the TYK2 gene within a Greek population. 27440135 2017
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.830 GeneticVariation BEFREE Finally, in a phenome-wide association study (PheWAS) assessing >500 phenotypes using electronic medical records (EMR) in >29,000 subjects, we found no convincing evidence for association of P1104A and A928V with complex phenotypes other than autoimmune diseases such as RA, SLE and IBD. 25849893 2015
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		C 0.830 GeneticVariation GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676 2015
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		G 0.830 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		G 0.830 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.830 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.830 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		0.810 GeneticVariation BEFREE These data establish the functional significance of the TYK2 I684S variant in psoriasis susceptibility. 29728633 2018
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		0.810 GeneticVariation BEFREE No significant changes in p-STAT4 for the psoriasis-associated variant rs34536443 was found. 29728633 2018
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		0.810 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		A 0.810 GeneticVariation GWASCAT Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		0.810 GeneticVariation GWASDB Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		G 0.810 GeneticVariation GWASCAT Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		A 0.810 GeneticVariation GWASCAT A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0033860
Disease:
Psoriasis 		A 0.810 GeneticVariation GWASDB A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0010346
Disease:
Crohn Disease 		0.800 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs12720356
rs12720356
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0010346
Disease:
Crohn Disease 		C 0.800 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
dbSNP: rs2304256
rs2304256
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0008312
Disease:
Primary biliary cirrhosis 		C 0.800 GeneticVariation GWASCAT International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. 26394269 2015
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C3898105
Disease:
Oligoarticular Juvenile Idiopathic Arthritis 		0.800 GeneticVariation GWASDB Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C3898105
Disease:
Oligoarticular Juvenile Idiopathic Arthritis 		0.800 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs2304256
rs2304256
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0008312
Disease:
Primary biliary cirrhosis 		0.800 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0008312
Disease:
Primary biliary cirrhosis 		0.800 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
dbSNP: rs34536443
rs34536443
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0008312
Disease:
Primary biliary cirrhosis 		G 0.800 GeneticVariation GWASCAT Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012