TYMS, thymidylate synthetase, 7298

N. diseases: 406; N. variants: 19
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3891167
rs3891167
Entrez Id: 7298;494514
Gene Symbol: TYMS;TYMSOS
TYMS;TYMSOS
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs66567989
rs66567989
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0524587
Disease:
Mean Corpuscular Volume (result)
G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs66567989
rs66567989
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs11873890
rs11873890
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0202236
Disease:
Triglycerides measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11873890
rs11873890
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0428472
Disease:
Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11873890
rs11873890
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0392885
Disease:
High density lipoprotein measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11873890
rs11873890
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C1445957
Disease:
Serum total cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2847153
rs2847153
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0200635
Disease:
Lymphocyte Count measurement
0.700 GeneticVariation GWASDB The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. 22286170 2012
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5'-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). 25648260 2015
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5'-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). 25648260 2015
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group. 22134752 2012
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group. 22134752 2012
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0023449
Disease:
Acute lymphocytic leukemia
0.030 GeneticVariation BEFREE Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques. 22838948 2012
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE Low dietary folate intake (P < 0.001), RFC1 G80A (OR: 1.38, 95% CI 1.06-1.81) and MTHFR C677T (OR: 1.74 (1.11-2.73) were independently associated with the breast cancer risk whereas cSHMT C1420T conferred protection (OR: 0.72, 95% CI 0.55-0.94). 21161404 2011
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0023449
Disease:
Acute lymphocytic leukemia
0.030 GeneticVariation BEFREE SLC19A1 80G > A emerged as the predominant polymorphism associated with risk of ALL. 20824655 2011
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE Low dietary folate intake (P < 0.001), RFC1 G80A (OR: 1.38, 95% CI 1.06-1.81) and MTHFR C677T (OR: 1.74 (1.11-2.73) were independently associated with the breast cancer risk whereas cSHMT C1420T conferred protection (OR: 0.72, 95% CI 0.55-0.94). 21161404 2011
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0023449
Disease:
Acute lymphocytic leukemia
0.030 GeneticVariation BEFREE For the first time, we associate the RFC1 80G>A and NNMT IVS -151C>T variants to an increased ALL susceptibility. 19020309 2009
dbSNP: rs1059394
rs1059394
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0017638
Disease:
Glioma
0.020 GeneticVariation BEFREE Our study provides evidence of the effect of <i>TYMS</i> rs1059394 on the susceptibility of glioma. 31632074 2019
dbSNP: rs1059394
rs1059394
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0017638
Disease:
Glioma
0.020 GeneticVariation BEFREE These results suggest that GOLGA7 (rs11337) polymorphism may play a role in the prognosis of glioma patients and that TYMS (rs1059394) is associated with glioma risk. 31525662 2019
dbSNP: rs2847153
rs2847153
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0017638
Disease:
Glioma
0.020 GeneticVariation BEFREE This study evaluated the role of TYMS (rs1059394, C > T, and rs2847153, G > A), RYR3 (rs1044129, G > A), KIAA0423 (rs1053667, T > C), and GOLGA7 (rs11337, G > T) polymorphisms for assessment of glioma risk and prognosis among the Chinese Han population. 31525662 2019
dbSNP: rs2847153
rs2847153
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0017638
Disease:
Glioma
0.020 GeneticVariation BEFREE However, no significant difference was found between rs2847153 and glioma risk in any genetic model (<i>P</i>﹥0.05). 31632074 2019
dbSNP: rs34743033
rs34743033
Entrez Id: 7298;494514
Gene Symbol: TYMS;TYMSOS
TYMS;TYMSOS
CUI: C0038362
Disease:
Stomatitis
0.020 GeneticVariation BEFREE The 2R2R genotype (rs34743033) was not significantly associated with developing MTX-induced oral mucositis compared with the 2R3R/3R3R genotypes, which was confirmed in a meta-analysis [odds ratio (OR): 1.17 (0.62-2.19)]. 30222710 2018
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C1956346
Disease:
Coronary Artery Disease
0.020 GeneticVariation BEFREE Gene-gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A). 25648260 2015
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5'-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). 25648260 2015
dbSNP: rs1448674651
rs1448674651
Entrez Id: 7298;55556
Gene Symbol: TYMS;ENOSF1
TYMS;ENOSF1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE The RFC1 80G>A polymorphism showed 1.32-fold risk (95% CI: 1.02-1.72) for SLE, while glutamate carboxypeptidase II (GCPII) 1561C>T showed reduced risk (OR: 0.47, 95% CI: 0.24-0.90). 24333266 2014