TMEM258, transmembrane protein 258, 746

N. diseases: 63; N. variants: 37
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0010346
Disease:
Crohn Disease
0.810 GeneticVariation BEFREE These relate to SNPs associated with Crohn's disease (CD; rs102275) and rheumatoid arthritis (RA; rs968567), which affect the expression of miR-1908-5p (p<sub>rs102275</sub> = 1.44e-20, p<sub>rs968567</sub> = 2.54e-14). 30143393 2018
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0010346
Disease:
Crohn Disease
C 0.810 GeneticVariation GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0010346
Disease:
Crohn Disease
C 0.810 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0009402
Disease:
Colorectal Carcinoma
G 0.800 GeneticVariation GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582 2019
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0009402
Disease:
Colorectal Carcinoma
G 0.800 GeneticVariation GWASCAT GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. 29471430 2018
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0202236
Disease:
Triglycerides measurement
T 0.800 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0009402
Disease:
Colorectal Carcinoma
G 0.800 GeneticVariation GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2016
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0009402
Disease:
Colorectal Carcinoma
G 0.800 GeneticVariation GWASDB Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0009402
Disease:
Colorectal Carcinoma
G 0.800 GeneticVariation GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0202177
Disease:
Phospholipid measurement
T 0.800 GeneticVariation GWASDB Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. 23362303 2013
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0202177
Disease:
Phospholipid measurement
C 0.800 GeneticVariation GWASDB Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. 23362303 2013
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0392885
Disease:
High density lipoprotein measurement
0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0202177
Disease:
Phospholipid measurement
0.800 GeneticVariation GWASCAT Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 22359512 2012
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0202177
Disease:
Phospholipid measurement
0.800 GeneticVariation GWASDB Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 22359512 2012
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0202177
Disease:
Phospholipid measurement
T 0.800 GeneticVariation GWASDB Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. 21829377 2011
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0524620
Disease:
Metabolic Syndrome X
0.800 GeneticVariation GWASDB A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148 2010
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0524620
Disease:
Metabolic Syndrome X
0.800 GeneticVariation GWASCAT A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148 2010
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0392885
Disease:
High density lipoprotein measurement
0.800 GeneticVariation GWASCAT A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148 2010
dbSNP: rs174537
rs174537
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0202236
Disease:
Triglycerides measurement
0.800 GeneticVariation GWASDB A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. 19074352 2008
dbSNP: rs1382225004
rs1382225004
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C4748946
Disease:
CARDIAC-UROGENITAL SYNDROME
0.800 GeneticVariation UNIPROT
dbSNP: rs1382225004
rs1382225004
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C4748946
Disease:
CARDIAC-UROGENITAL SYNDROME
A 0.800 CausalMutation CLINVAR
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0523829
Disease:
Phosphatidylcholine measurement
C 0.700 GeneticVariation GWASCAT Genetic architecture of human plasma lipidome and its link to cardiovascular disease. 31551469 2019
dbSNP: rs102275
rs102275
Entrez Id: 746
Gene Symbol: TMEM258
TMEM258
CUI: C0014772
Disease:
Red Blood Cell Count measurement
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs174529
rs174529
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0202236
Disease:
Triglycerides measurement
0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174529
rs174529
Entrez Id: 745;746
Gene Symbol: MYRF;TMEM258
MYRF;TMEM258
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement
0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019