rs121907900
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Denys-Drash Syndrome
0.710
GeneticVariation
BEFREE
WT1 gene mutations have been described in 46,XY patients with ambiguous genitalia or complete gonadal dysgenesis with or without Wilms' tumor, nephropathy, gonadoblastoma, and other defects, e.g., cryptorchidism or hypospadias. p.R462W is a hot spot mutation in exon 9 and is the most common mutation in patients with Denys-Drash syndrome .
29320783
2017
rs1423753702
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Nephroblastoma
0.710
GeneticVariation
BEFREE
We report on a novel WT1 nonsense mutation (c.1105C>T ), introducing a premature stop codon in exon 8 (p.Q369X), in a young XY male patient who presented with bilateral cryptorchidism, nystagmus, mild proteinuria and WT , but no sign of severe nephropathy.
19048299
2009
rs1423753702
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Nephroblastoma
A
0.710
CausalMutation
CLINVAR
Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.
9108089
1997
rs121907900
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Denys-Drash Syndrome
A
0.710
CausalMutation
CLINVAR
rs3809060
WT1;WT1-AS
Cardiovascular Diseases
0.700
GeneticVariation
GWASCAT
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
30595370
2019
rs5030179
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Systolic Pressure
0.700
GeneticVariation
GWASCAT
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
30595370
2019
rs5030317
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Birth Weight
C
0.700
GeneticVariation
GWASCAT
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
31043758
2019
rs7110547
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Waist-Hip Ratio
0.700
GeneticVariation
GWASCAT
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
30595370
2019
rs4986811
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Soluble Interleukin 6 Receptor Measurement
G
0.700
GeneticVariation
GWASCAT
Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination.
29253144
2018
rs2234584
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Nephroblastoma
0.700
GeneticVariation
UNIPROT
Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.
27854360
2017
rs587776576
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Frasier Syndrome
T
0.700
CausalMutation
CLINVAR
Spectrum of mutations in Chinese children with steroid-resistant nephrotic syndrome.
28204945
2017
rs1564969626
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Denys-Drash Syndrome
G
0.700
GeneticVariation
CLINVAR
Next-generation sequencing for diagnosis of rare diseases in the neonatal intensive care unit.
27241786
2016
rs2234584
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Nephroblastoma
0.700
GeneticVariation
UNIPROT
ACMG policy statement: updated recommendations regarding analysis and reporting of secondary findings in clinical genome-scale sequencing.
25356965
2015
rs3809060
WT1;WT1-AS
Hernia, Inguinal
G
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.
26686553
2015
rs587776576
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Frasier Syndrome
T
0.700
CausalMutation
CLINVAR
Clinical and molecular characterization of patients with heterozygous mutations in wilms tumor suppressor gene 1.
25818337
2015
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial.
24659740
2014
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
Relapse assessment following allogeneic SCT in patients with MDS and AML.
24671364
2014
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy.
24521058
2014
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
Wilms' Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses.
24422723
2014
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
Overexpression of Wilms tumor 1 gene as a negative prognostic indicator in acute myeloid leukemia.
24667279
2014
rs1057519745
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Leukemia, Myelocytic, Acute
CACCGTACA
0.700
GeneticVariation
CLINVAR
WT1 overexpression affecting clinical outcome in non-hodgkin lymphomas and adult acute lymphoblastic leukemia.
24374862
2014
rs587776576
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Frasier Syndrome
T
0.700
CausalMutation
CLINVAR
Retrospective mutational analysis of NPHS1, NPHS2, WT1 and LAMB2 in children with steroid-resistant focal segmental glomerulosclerosis - a single-centre experience.
24856380
2014
rs121907909
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Nephroblastoma
A
0.700
CausalMutation
CLINVAR
Genetic screening in adolescents with steroid-resistant nephrotic syndrome.
23515051
2013
rs121907909
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
WAGR Syndrome
A
0.700
CausalMutation
CLINVAR
Genetic screening in adolescents with steroid-resistant nephrotic syndrome.
23515051
2013
rs121907909
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
Denys-Drash Syndrome
A
0.700
CausalMutation
CLINVAR
Genetic screening in adolescents with steroid-resistant nephrotic syndrome.
23515051
2013