XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0262972
Disease:
Acute dermatitis
0.010 GeneticVariation BEFREE The relationship between XRCC1 194Arg/Trp and acute dermatitis, and mucositis was not found. 23375119 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0262972
Disease:
Acute dermatitis
0.010 GeneticVariation BEFREE Our investigation shows, for the first time, that patients with the XRCC1 399Arg/Gln genotype were more likely to experience severe acute dermatitis and oral mucositis. 23375119 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0023449
Disease:
Acute lymphocytic leukemia
0.010 GeneticVariation BEFREE In stratified analyses by tumor type, Arg399Gln was associated with higher acute lymphoblastic leukemia (ALL) risk (AA vs. GG, OR  =  1.50, 95% CI: 1.11-2.02; AA+GA vs. GG, OR  =  1.35, 95% CI: 1.02-1.78). 24363792 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1290073
Disease:
Acute mucositis
0.010 GeneticVariation BEFREE Our meta-analysis demonstrated that <i>XRCC1</i> rs25487 Arg399Gln polymorphism had a significant predictive value and might predict a risk of severely acute RT-induced adverse effects, especially in acute mucositis and acute gastrointestinal and genitourinary toxicity, or in patients with head and neck irradiation. 30013370 2018
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE This is the first report that the XRCC1 Arg399Gln polymorphism might be important in relation to the risk of adenocarcinoma/adenosquamous carcinoma of the cervix. 15990162 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0001418
Disease:
Adenocarcinoma
0.020 GeneticVariation BEFREE XRCC1 Arg399Gln showed a borderline significant association with adenocarcinoma (adjusted OR 1.89, 95%CI 1.00-3.57, p=0.051). 21198260 2010
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE The associations between the OGG1 Cys/Cys genotype and adenocarcinoma risk and between XRCC1 Arg194Trp polymorphism and lung cancer risk among heavy smokers remained robust given prior probabilities of 25% (FPRP = 0.238) and 10% (FPRP = 0.276), respectively. 15840879 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279628
Disease:
Adenocarcinoma Of Esophagus
0.020 GeneticVariation BEFREE Although no significant relationships were found for the XRCC1 Arg399Gln polymorphism alone, this polymorphism did modify the relationship between XPD Lys751Gln and EA risk; when both polymorphisms were evaluated together, adding the number of variant alleles of the two polymorphisms resulted in a significant trend (trend test, P = 0.008); compared with individuals with no variant alleles (n = 88), the adjusted ORs of developing EA are 1.49 (95% CI: 0.88-2.59), 1.69 (95% CI: 0.98-2.96) and 2.58 (95% CI: 1.31-5.06) for one (n = 195), two (n = 166) and three or four variant alleles (n = 70), respectively. 17264068 2007
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279628
Disease:
Adenocarcinoma Of Esophagus
0.020 GeneticVariation BEFREE The protective effect of the homozygous variant of XRCC1 Arg399Gln for GERD and BE suggests that base excision repair alterations may occur early in progression to EADC, likely in response to GERD-induced endogenous oxidative or inflammatory DNA damage. 15878910 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0281361
Disease:
Adenocarcinoma of pancreas
0.010 GeneticVariation BEFREE A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. 12183419 2002
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0001430
Disease:
Adenoma
0.010 GeneticVariation BEFREE High omega-6/omega-3 polyunsaturated fatty acid ratios were associated with adenoma risk among subjects with the XRCC1 codon 194 Arg/Arg and codon 399 Gln/Gln or the codon 194 Arg/Trp or Trp/Trp and codon 399 Arg/Arg or Arg/Gln combined genotypes (P for interaction = 0.026). 15767338 2005
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1302401
Disease:
Adenoma of large intestine
0.010 GeneticVariation BEFREE Using a large sigmoidoscopy-based case-control study (753 cases and 799 controls) in Los Angeles County, we investigated possible associations between single-nucleotide polymorphisms in the XRCC1 (codons 194 Arg/Trp and codon 399 Arg/Gln) and XRCC3 (codon 241 Thr/Met) genes and colorectal adenoma risk and their possible role as modifiers of the effect of monounsaturated fatty acid, the ratio of omega-6/omega-3 polyunsaturated fatty acids, and antioxidant intake. 15767338 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1302401
Disease:
Adenoma of large intestine
0.010 GeneticVariation BEFREE Using a large sigmoidoscopy-based case-control study (753 cases and 799 controls) in Los Angeles County, we investigated possible associations between single-nucleotide polymorphisms in the XRCC1 (codons 194 Arg/Trp and codon 399 Arg/Gln) and XRCC3 (codon 241 Thr/Met) genes and colorectal adenoma risk and their possible role as modifiers of the effect of monounsaturated fatty acid, the ratio of omega-6/omega-3 polyunsaturated fatty acids, and antioxidant intake. 15767338 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0751606
Disease:
Adult Acute Lymphocytic Leukemia
0.010 GeneticVariation BEFREE In stratified analyses by tumor type, Arg399Gln was associated with higher acute lymphoblastic leukemia (ALL) risk (AA vs. GG, OR  =  1.50, 95% CI: 1.11-2.02; AA+GA vs. GG, OR  =  1.35, 95% CI: 1.02-1.78). 24363792 2013
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1332201
Disease:
Adult Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma. 17666372 2007
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0278878
Disease:
Adult Glioblastoma
0.020 GeneticVariation BEFREE Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ(2) = 6.558; p = 0.0053). 26511493 2016
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0278878
Disease:
Adult Glioblastoma
0.020 GeneticVariation BEFREE Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities. 23383237 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279607
Disease:
Adult Hepatocellular Carcinoma
0.010 GeneticVariation BEFREE This meta-analysis suggests the participation of XRCC1 Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians. 24205095 2013
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0220597
Disease:
Adult Hodgkin Lymphoma
0.010 GeneticVariation BEFREE We observed that, in combination, allelic variants in the XPC Ala499Val, NBN Glu185Gln, XRCC3 Thr241Me, XRCC1 Arg194Trp, and XRCC1 399Gln polymorphisms modify the risk for developing HL. 21374732 2011
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0220630
Disease:
Adult Liver Carcinoma
0.010 GeneticVariation BEFREE Trial sequential analysis (TSA), false-positive report probabilities (FPRP), and combined genotype analysis revealed that XRCC1 Arg399Gln is mainly associated with susceptibility to liver cancer. 30408066 2018
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1332206
Disease:
Adult Lymphoma
0.010 GeneticVariation BEFREE In this work, we retrospectively evaluated the influence of an XRCC1 polymorphism (rs25487) on the treatment results in a series of 73 patients with lymphoma subjected to ASCT. 21463129 2011
dbSNP: rs25489
rs25489
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C3900098
Disease:
Adult Myelodysplastic Syndrome
0.010 GeneticVariation BEFREE Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome. 26482462 2016
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0242383
Disease:
Age related macular degeneration
0.010 GeneticVariation BEFREE Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to analyze XPD Asp312Asn and Lys751Gln and XRCC1 Arg194Trp and Arg399Gln in 120 patients with AMD (65 with dry type and 55 with wet type) and in age-matched 205 disease-free control subjects. 20375340 2010
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0242383
Disease:
Age related macular degeneration
0.010 GeneticVariation BEFREE Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to analyze XPD Asp312Asn and Lys751Gln and XRCC1 Arg194Trp and Arg399Gln in 120 patients with AMD (65 with dry type and 55 with wet type) and in age-matched 205 disease-free control subjects. 20375340 2010
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0036646
Disease:
Age-related cataract
0.020 GeneticVariation BEFREE Polymorphisms of DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln), and the risk of age-related cataract: a meta-analysis. 25285569 2015