XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1001581
rs1001581
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.010 GeneticVariation BEFREE Larger studies that will focus on the role of the rs1001581 and rs2293036 htSNPs and haplotypes for developing NSCLC are needed in the future. 20978448 2010
dbSNP: rs1041258260
rs1041258260
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.010 GeneticVariation BEFREE The aim of the present study was to analyze the effect of XPG Asp 1104His and XRCC1 Arg309Gln polymorphisms on risk of prostate cancer in north Indian population. 21670956 2012
dbSNP: rs1041258260
rs1041258260
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0600139
Disease:
Prostate carcinoma
0.010 GeneticVariation BEFREE The aim of the present study was to analyze the effect of XPG Asp 1104His and XRCC1 Arg309Gln polymorphisms on risk of prostate cancer in north Indian population. 21670956 2012
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE These findings indicate that the c.1804C>A genetic polymorphism of XRCC1 gene is not significantly associated with BC susceptibility in the Chinese women. 24277466 2013
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population. 27323144 2016
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0017638
Disease:
Glioma
0.010 GeneticVariation BEFREE We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001). 24375631 2014
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE These findings indicate that the c.1804C>A genetic polymorphism of XRCC1 gene is not significantly associated with BC susceptibility in the Chinese women. 24277466 2013
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0476089
Disease:
Endometrial Carcinoma
0.010 GeneticVariation BEFREE As for c.1804C>A, the CC genotype significantly increased t</span>he risk of EC in comparison with CC wild genotype (OR=2.77, 95% CI 1.38-5.58, χ(2)=8.54, P=0.003). 25445285 2015
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population. 27323144 2016
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population. 27323144 2016
dbSNP: rs1214285376
rs1214285376
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE Our findings support that c.1804C>A genetic polymorphism of XRCC1 gene plays a genetic influence on the susceptibility to HCC in the studied population. 24526467 2014
dbSNP: rs1395746092
rs1395746092
Entrez Id: 7515;390940
Gene Symbol: XRCC1;PINLYP
XRCC1;PINLYP
CUI: C0008626
Disease:
Congenital chromosomal disease
0.010 GeneticVariation BEFREE We analysed the associations between genetic polymorphisms in genes coding for DNA repair enzymes XPD (exon 23 A --> C, K751Q), XPG (exon 15 G --> C, D1104H), XPC (exon 15 A --> C, K939Q), XRCC1 (exon 10 G --> A, R399Q) and XRCC3 (exon 7 C --> T, T241 M) and the levels of chromosomal aberrations (CAs) and single-strand breaks (SSBs) in peripheral lymphocytes in a central European population. 14729591 2004
dbSNP: rs139599857
rs139599857
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C2239176
Disease:
Liver carcinoma
0.020 GeneticVariation BEFREE We conclude that the T-allele of c.1254C>T (rs2293035) and the C allele of c.1517G>C (rs139599857) genetic variants may be associated with increased HCC risk among chronic hepatitis C patients. 31025604 2019
dbSNP: rs139599857
rs139599857
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C2239176
Disease:
Liver carcinoma
0.020 GeneticVariation BEFREE Association analyses suggested that these two genetic variants were statistically associated with the increased risk of HCC in all genetic models (for c.1254C>T, TT versus CC: OR = 2.30, 95% CI 1.61-3.28; CT versus CC: OR = 1.32, 95% CI 1.05-1.67; TT/CT versus CC: OR = 1.50, 95% CI 1.20-1.86; TT versus CT/CC: OR = 2.00, 95% CI 1.43-2.80; T versus C: OR = 1.47, 95% CI 1.25-1.73; for c.1517G>C, CC versus GG: OR = 1.90, 95% CI 1.34-2.69; GC versus GG: OR = 1.56, 95% CI 1.24-1.97; CC/GC versus GG: OR = 1.63, 95% CI 1.31-2.03; CC versus GC/GG: OR = 1.52, 95% CI 1.10-2.11; C versus G: OR = 1.45, 95% CI 1.23-1.70). 23984316 2013
dbSNP: rs139599857
rs139599857
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0235974
Disease:
Pancreatic carcinoma
0.010 GeneticVariation BEFREE Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population. 25036351 2014
dbSNP: rs139599857
rs139599857
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population. 25036351 2014
dbSNP: rs139834892
rs139834892
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C1332977
Disease:
Childhood Leukemia
0.010 GeneticVariation BEFREE Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}. 30320340 2018
dbSNP: rs139834892
rs139834892
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0242006
Disease:
Myelofibrosis due to another disorder
0.010 GeneticVariation BEFREE Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}. 30320340 2018
dbSNP: rs139834892
rs139834892
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0023418
Disease:
leukemia
0.010 GeneticVariation BEFREE Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}. 30320340 2018
dbSNP: rs1402607735
rs1402607735
Entrez Id: 7515;390940
Gene Symbol: XRCC1;PINLYP
XRCC1;PINLYP
CUI: C0268135
Disease:
Xeroderma pigmentosum, group A
0.010 GeneticVariation BEFREE Polymerase chain reaction based analysis was used to resolve the XRCC1 codon 107, 194, 280, and 399; XPA A23G; XPA codon 228; and XPD codon 751 polymorphisms. 20431719 2010
dbSNP: rs1402607735
rs1402607735
Entrez Id: 7515;390940
Gene Symbol: XRCC1;PINLYP
XRCC1;PINLYP
CUI: C0268138
Disease:
Xeroderma Pigmentosum, Complementation Group D
0.010 GeneticVariation BEFREE There is no correlation between pterygium and XRCC1 codon 107 and 280, XPA A23G, and XPD codon 751 polymorphisms. 20431719 2010
dbSNP: rs1436873982
rs1436873982
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0268138
Disease:
Xeroderma Pigmentosum, Complementation Group D
0.010 GeneticVariation BEFREE Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G>A), ERCC2/XPD (Lys751Gln) and ERCC5/XPD (His46His); the BER genes APE1/APEX (Ile64Val), OGG1 (Ser326Cys), PCNA (1876A>G) and XRCC1 (Arg194Trp, Arg280His, Arg399Gln); and the DSB-R genes ATR (Thr211Met), NBS1 (Glu185Gln), XRCC2 (Arg188His) and XRCC9 (Thr297Ile) modulate NSCLC risk. 16195237 2006
dbSNP: rs1436873982
rs1436873982
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.010 GeneticVariation BEFREE Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G>A), ERCC2/XPD (Lys751Gln) and ERCC5/XPD (His46His); the BER genes APE1/APEX (Ile64Val), OGG1 (Ser326Cys), PCNA (1876A>G) and XRCC1 (Arg194Trp, Arg280His, Arg399Gln); and the DSB-R genes ATR (Thr211Met), NBS1 (Glu185Gln), XRCC2 (Arg188His) and XRCC9 (Thr297Ile) modulate NSCLC risk. 16195237 2006
dbSNP: rs148611340
rs148611340
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE The association analyses suggested that these two genetic variants were statistically associated with the increased risk of gastric cancer (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17-1.77; for c.1779C>G, G versus C: OR = 1.51, 95% CI 1.22-1.86). 24779987 2014
dbSNP: rs148611340
rs148611340
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE The allele A and genotype AA of c.1161G>A and allele G and genotype GG of c.177</span>9C>G genetic variants may enhance lung cancer susceptibility. 25146668 2014