Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population. 25024628 2014
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population. 23317245 2012
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Comparing the CRC cases versus the controls the OR was 0.60 (95%CI 0.27-1.31) for the heterozygous polymorphic genotype of SNP rs1799782 and 1.47 (95%CI 0.81-2.65) for the homozygous polymorphic genotype of SNP rs25487. 21612998 2011
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Comparing with individuals carrying XRCC1 399Arg/Arg genotype, the subjects with 399Arg/Gln (OR=1.46, 95% CI 1.06-2.01) or 399Gln/Gln genotype (OR=1.93, 95% CI 1.05-3.54) had a significantly increased risk for CRC. 26271249 2015
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE However, the distributions of OGG1 Ser326Cys and XRCC1 Arg399Gln were not associated with a colorectal cancer risk. 18823566 2008
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE However, we showed that the carriers of allele A in XRCC1 (rs25487, G > A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12-2.41, p = 0.012). 27328741 2016
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In conclusion, APE1 (Asp148Glu), PARP1 (Ala762Val), and XRCC1 (Arg399Gln, Arg194Trp) were associated with the susceptibility to CRC, but were not associated with the prognosis of CRC. 23430444 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In this work, we evaluated associations between the repair efficiency of oxidative DNA lesions and single-nucleotide polymorphisms of BER genes: the 194Trp/Arg and the 399Arg/Gln XRCC1, the 326Ser/Cys OGG1 and the 324Gln/His MUTYH and CRC occurrence in a Polish population. 23618615 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association between Arg399Gln polymorphism and CRC risk was observed in both total population analyses and subgroup analyses based on ethnicity (OR(Co-dominant model) = 1.04, 95% CI 0.74-1.45, P (OR) = 0.82; OR(Dominant model) = 1.02, 95% CI 0.80-1.30, P (OR) = 0.88; OR (Recessive model) = 1.04, 95% CI 0.81-1.34, P (OR) = 0.78). 20033188 2010
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association between the XRCC1 R399Q</span> polymorphism and CRC risk was observed in the Chinese Han population (Gln/Gln vs. Arg/Arg, OR = 1.26, 95% CI = 0.85-1.87, P OR = 0.242; Arg/Gln vs. Arg/Arg, OR = 0.95, 95% CI = 0.70-1.18, P OR = 0.651; dominant model, OR = 1.09, 95% CI = 0.86-1.38, P OR = 0.480; and recessive model, OR = 1.24, 95% CI = 0.91-1.70, P OR = 0.177). 25582318 2015
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association of Arg399Gln SNP with any clinicopathological parameters of CRC was found. 24377605 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our meta-analysis provides an evidence for the association between XRCC1 Arg399Gln polymorphism and colorectal cancer</span> risk in Chinese population, and XRCC1 Arg399Gln variant genotypes contribute to increased risk of colorectal cancer in Chinese. 23712778 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer. 19031937 2009
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer. 15914278 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M (rs861539) have been implicated in colorectal cancer (CRC) risk, but the results are conflicting. 23271134 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Six gene polymorphisms functional in drug-metabolism - GSTP1 Ile105Val, ABCB1 Ile1145Ile, MTHFR Ala222Val, TYMS double (2R) or triple (3R) tandem repeat - and DNA-repair genes - ERCC2 Lys751Gln and XRCC1 Arg399Gln - were assessed in 201 CRC patients using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) technique and DNA sequencing. 18267032 2008
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The relationships between the X-ray repair cross-complementing 1 (XRCC1) Arg399Gln polymorphism (rs25487, G > A) and responses to platinum-based chemotherapy of gastric and colorectal cancer patients are controversial. 24224851 2014
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The results suggest that XRCC1 Arg399Gln polymorphisms is associated with the response to oxaliplatin-based chemotherapy and time to progression in advanced colorectal cancer in Chinese population. 22549274 2012
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The statistically significant association between the XRCC1 Arg399Gln polymorphism and CRC risk was observed among studies with high quality and in Asians, but not in Caucasians. 23188703 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE These results indicate that XRCC1 Arg399Gln polymorphism is associated with response to oxaliplantin-based chemotherapy and TTP in advanced colorectal cancer in Chinese population. 23327191 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium. 25921133 2015
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE This study was designed to examine the polymorphisms associated with three DNA repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, and investigate their role as susceptibility markers for colorectal cancer. 15679883 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk. 21037106 2010
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE We performed a case-control study (51 cases and 100 controls) to test the association between two polymorphisms: Arg399Gln in the XRCC1 gene and Thr241Met in the XRCC3 gene and colorectal cancer risk. 15354414 2004