Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In conclusion, APE1 (Asp148Glu), PARP1 (Ala762Val), and XRCC1 (Arg399Gln, Arg194Trp) were associated with the susceptibility to CRC, but were not associated with the prognosis of CRC. 23430444 2013
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The presence of a variant 194Trp allele in the Arg194Trp SNP was significantly associated with a higher risk of GIC, especially with gastric and colorectal cancers. 27221877 2016
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Results showed that Trp/Trp genotype of XRCC1 Arg194Trp and AA genotype of ERCC1 rs2336219 have a significantly increased risk of CRC; Trp allele of XRCC1 Arg194Trp and CC genotype of ERCC1 rs735482 were associated with lower response to oxaliplatin-based chemotherapy, a shorter survival and a higher risk of relapse or metastasis. 25690281 2015
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk. 21037106 2010
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Comparing the CRC cases versus the controls the OR was 0.60 (95%CI 0.27-1.31) for the heterozygous polymorphic genotype of SNP rs1799782 and 1.47 (95%CI 0.81-2.65) for the homozygous polymorphic genotype of SNP rs25487. 21612998 2011
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No association is found between the polymorphisms in XRCC1 (Arg399Gln, Arg280His, and Arg194Trp) and risk of colorectal cancer. 20033188 2010
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In this work, we evaluated associations between the repair efficiency of oxidative DNA lesions and single-nucleotide polymorphisms of BER genes: the 194Trp/Arg and the 399Arg/Gln XRCC1, the 326Ser/Cys OGG1 and the 324Gln/His MUTYH and CRC occurrence in a Polish population. 23618615 2013
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results suggest an increased risk for CRC in individuals with XRCC1 Arg194Trp polymorphism suggesting BER repair pathway modulates the risk of developing colorectal cancer in the Kashmiri population. 26434847 2015
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M (rs861539) have been implicated in colorectal cancer (CRC) risk, but the results are conflicting. 23271134 2013
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The purpose of this study is to evaluate the role of XRCC1 R399Q, R194W, and XRCC3 T241M genotypes in colorectal cancer susceptibility. 19915856 2010
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Related databases of Medline, CNKI, and Wanfang were systematic searched for the studies related to XRCC1 rs1799782 C>T polymorphisms and colorectal cancer risk in Chinese Han population. 28230032 2016
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Therefore, we examined the associations of XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms with colorectal cancer and the impact of the association between alcohol consumption and colorectal cancer risk. 22186158 2012
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer. 19031937 2009
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The present meta-analysis suggests that the XRCC1 Arg194Trp polymorphism may modify the risk for CRC, particularly colon cancer. 23857281 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association of Arg399Gln SNP with any clinicopathological parameters of CRC was found. 24377605 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE These results indicate that XRCC1 Arg399Gln polymorphism is associated with response to oxaliplantin-based chemotherapy and TTP in advanced colorectal cancer in Chinese population. 23327191 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association between Arg399Gln polymorphism and CRC risk was observed in both total population analyses and subgroup analyses based on ethnicity (OR(Co-dominant model) = 1.04, 95% CI 0.74-1.45, P (OR) = 0.82; OR(Dominant model) = 1.02, 95% CI 0.80-1.30, P (OR) = 0.88; OR (Recessive model) = 1.04, 95% CI 0.81-1.34, P (OR) = 0.78). 20033188 2010
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer. 19031937 2009
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In conclusion, APE1 (Asp148Glu), PARP1 (Ala762Val), and XRCC1 (Arg399Gln, Arg194Trp) were associated with the susceptibility to CRC, but were not associated with the prognosis of CRC. 23430444 2013
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE No significant association between the XRCC1 R399Q</span> polymorphism and CRC risk was observed in the Chinese Han population (Gln/Gln vs. Arg/Arg, OR = 1.26, 95% CI = 0.85-1.87, P OR = 0.242; Arg/Gln vs. Arg/Arg, OR = 0.95, 95% CI = 0.70-1.18, P OR = 0.651; dominant model, OR = 1.09, 95% CI = 0.86-1.38, P OR = 0.480; and recessive model, OR = 1.24, 95% CI = 0.91-1.70, P OR = 0.177). 25582318 2015
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Comparing with individuals carrying XRCC1 399Arg/Arg genotype, the subjects with 399Arg/Gln (OR=1.46, 95% CI 1.06-2.01) or 399Gln/Gln genotype (OR=1.93, 95% CI 1.05-3.54) had a significantly increased risk for CRC. 26271249 2015
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer. 15914278 2005
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE However, the distributions of OGG1 Ser326Cys and XRCC1 Arg399Gln were not associated with a colorectal cancer risk. 18823566 2008
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Six gene polymorphisms functional in drug-metabolism - GSTP1 Ile105Val, ABCB1 Ile1145Ile, MTHFR Ala222Val, TYMS double (2R) or triple (3R) tandem repeat - and DNA-repair genes - ERCC2 Lys751Gln and XRCC1 Arg399Gln - were assessed in 201 CRC patients using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) technique and DNA sequencing. 18267032 2008
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk. 21037106 2010