Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE In conclusion, Arg194Trp genetic polymorphism may be associated with an increased risk for developing ESCC and a study with the larger sample size is needed to further evaluate gene-environment interaction on XRCC1 polymorphisms and ESCC risk. 19444915 2009
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE For Arg399Gln, there was no effect in dominant modeling (Arg/Gln+Gln/Gln vs. Arg/Arg: OR 0.92; 95% CI 0.80-1.06; p = 0.25), and the variant Gln/Gln homozygote was not associated with ESCC risk (OR 1.29; 95% CI 0.79-2.10; p = 0.31), either. 19444915 2009
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg --> Trp) and codon 399 (Arg --> Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals. 15225899 2004
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg --> Trp) and codon 399 (Arg --> Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals. 15225899 2004
dbSNP: rs1799782
rs1799782
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE We therefore investigated the associations between genetic polymorphisms in the DNA repair genes XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) and risk of ESCC in an at-risk Chinese population. 12124811 2002
dbSNP: rs25487
rs25487
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.030 GeneticVariation BEFREE However, the XRCC1 Arg399Gln polymorphism was not significantly associated with risk of ESCC, with the adjusted OR being 0.87 (95% CI 0.55-1.37). 12124811 2002
dbSNP: rs3213245
rs3213245
Entrez Id: 7515;390940
Gene Symbol: XRCC1;PINLYP
XRCC1;PINLYP
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.010 GeneticVariation BEFREE Recently, we reported a SNP (rs3213245, -77T>C) in the XRCC1 gene 5' untranslated region (UTR) was significantly associated with the risk of developing esophageal squamous-cell carcinoma. 16652158 2006