rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC .
31478224
2020
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
There was no association between the risk of HCC development and t he XRCC1 Arg280His or XRCC1 Arg399 Gln genotypes.
29935355
2018
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
However, there was no association between Arg194Trp or Arg280His and the risk of HCC .
30408066
2018
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
In overall analyses, the minor alleles of four variants, Arg280His (odds ratio, 95% confidence interval, P: 1.37, 1.13-1.66, 0.001), Thr241Met (1.93, 1.17-3.20, 0.011), Asp312Asn (1.22, 1.08-1.38, 0.001) and Lys751Gln (1.42, 1.02-1.97, 0.038), were associated with the significant risk for hepatocellular carcinoma .
27306318
2016
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
Our analysis suggests that the XRCC1 Arg280His polymorphism is ass ociated with a higher risk of HCC .
26125922
2015
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
The XRCC1 Arg280His gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.
23679314
2013
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
No evidence of association of Arg194Trp (980 HCC cases and 966 controls) and Arg280His (1,200 HCC cases and 1,236 controls) with HCC risk was found.
23055199
2013
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
More rigorous association studies are needed to verify the involvement of XRCC1 Arg280His polymorphism in HCC susceptibility.
22919255
2012
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
In contrast, there was no association between HCC susceptibility and the distribution of XRCC1 His 280 His and Arg280His .
22565339
2012
rs25489
×
Entrez Id:
7515
Gene Symbol:
XRCC1
XRCC1
Liver carcinoma
0.100
GeneticVariation
BEFREE
Interestingly, the risk for HCC was further enhanced by 35.96 (95% CI = 11.64-110.91; P < 0.001) and 5.28 times (95% CI = 2.81-9.09; P < 0.001) when the genotype Arg280His was found in association with Arg194Trp and Arg399Gln, respectively.
19194663
2009