PALB2, partner and localizer of BRCA2, 79728

N. diseases: 260; N. variants: 410
Disease: Neoplastic Syndromes, Hereditary ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif. 28158555 2017
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. 27433846 2016
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. 27595995 2016
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Mutation screening of PALB2 in clinically ascertained families from the Breast Cancer Family Registry. 25575445 2015
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study. 25356972 2015
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls. 26283626 2015
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada. 25225577 2014
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Breast-cancer risk in families with mutations in PALB2. 25099575 2014
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families. 23448497 2013
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR The incidence of PALB2 c.3113G>A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia. 23471749 2013
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Rare germline mutations in PALB2 and breast cancer risk: a population-based study. 22241545 2012
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer. 21285249 2011
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer. 21409391 2011
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR A PALB2 mutation associated with high risk of breast cancer. 21182766 2010
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families. 18302019 2009
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. 19264984 2009
dbSNP: rs180177132
rs180177132
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. 17200668 2007