DisGeNET - a database of gene-disease associations

THSD4, thrombospondin type 1 domain containing 4, 79875

N. diseases: 22; N. variants: 20

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1441357

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0410702
Disease:

Adolescent idiopathic scoliosis

0.700

GeneticVariation

GWASCAT

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

30019117

2018

dbSNP:

rs142200609

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

26830138

2016

dbSNP:

rs12102112

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

28166215

2017

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs2119568

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs4316710

Entrez Id:	79875;107984716
Gene Symbol:	THSD4;LOC107984716

THSD4;LOC107984716

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.010

GeneticVariation

BEFREE

We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).

22461431

2012

dbSNP:

rs7180092

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.700

GeneticVariation

GWASDB

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

17463246

2007

dbSNP:

rs11631778

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

27841878

2017

dbSNP:

rs28529655

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

30578418

2019

dbSNP:

rs12899618

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0016529
Disease:

Forced expiratory volume function

0.700

GeneticVariation

GWASDB

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

23284291

2012

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0016529
Disease:

Forced expiratory volume function

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs62015883

Entrez Id:	79875;107984716
Gene Symbol:	THSD4;LOC107984716

THSD4;LOC107984716

CUI:	C0016529
Disease:

Forced expiratory volume function

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C1518922
Disease:

peak expiratory flow (procedure)

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs11855326

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11858540

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs12441227

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs12899618

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies five loci associated with lung function.

20010834

2010

dbSNP:

rs1441361

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs17786786

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs1837762

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs6494904

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs8033889

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11855326

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11858540

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014