PTGES2, prostaglandin E synthase 2, 80142

N. diseases: 23; N. variants: 1
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE In this study we tested whether the type 2 diabetes mellitus associated prostaglandin E synthase 2 arginine to histidine polymorphism at position 298 (R298H) influences prostaglandin E2 levels in humans. 19268562 2009
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE The H-allele of the R298H polymorphism in the prostaglandin E synthase 2 (PTGES2) gene was associated with lower risk of diabetes type 2. 19371221 2009
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE We obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes. 17566096 2007
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE In a recent study, we found an association of the minor PTGES2 Arg298His allele and lower risk of type 2 diabetes mellitus in the European Investigation into Cancer and Nutrition (EPIC) and Cooperative Health Research in the Augsburg Region (KORA) cohorts. 17979097 2007
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0524620
Disease:
Metabolic Syndrome X 		0.010 GeneticVariation BEFREE Here, we employed our Metabolic Intervention Cohort Kiel (MICK) to assess the influence of the PTGES2 Arg298His polymorphism on a wider scale of parameters of the metabolic syndrome and postprandial metabolism. 17979097 2007
dbSNP: rs13283456
rs13283456
Entrez Id: 80142
Gene Symbol: PTGES2
PTGES2
CUI: C0271650
Disease:
Impaired glucose tolerance 		0.010 GeneticVariation BEFREE The PTGES2 Arg298His polymorphism was reinvestigated in a population-based cross-sectional study (Cooperative Health Research in the Augsburg Region) consisting of 239 individuals with impaired glucose tolerance, 226 with type 2 diabetes, and 863 normoglycemic controls. 17566096 2007