CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006826
Disease:
Malignant Neoplasms 		0.050 GeneticVariation BEFREE Moreover, globally caspase and BER polymorphisms influenced the development of new nonmyeloid malignancies [CASP8 Asp270His (OR=5.90; 95% CI, 1.42‑24.62) and XRCC1 Arg399Gln (OR=0.27; 95% CI, 0.07‑1.03)]. 30320340 2018
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006826
Disease:
Malignant Neoplasms 		0.050 GeneticVariation BEFREE For D302H polymorphism, data indicated the association of allele C with decreased cancer risk (Overall, C versus G: OR=0.93; 95% CI: 0.86-0.99, p=0.03). 25553350 2014
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006826
Disease:
Malignant Neoplasms 		0.050 GeneticVariation BEFREE A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polymorphism are reportedly important in cancer development, but no reported study has assessed the associations of these genetic variations with risk of head and neck cancer. 20086182 2010
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006826
Disease:
Malignant Neoplasms 		0.050 GeneticVariation BEFREE These results suggest that CASP8 D302H and -652 6N del polymorphisms are potential biomarkers for cancer risk. 20176653 2010
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006826
Disease:
Malignant Neoplasms 		0.050 GeneticVariation BEFREE In conclusion, both CASP8 -652 6N del and D302H polymorphisms are associated with reduced cancer risk. 19629679 2010