Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs778241955
rs778241955
Entrez Id: 7103;8549
Gene Symbol: TSPAN8;LGR5
TSPAN8;LGR5
CUI: C0553723
Disease:
Squamous cell carcinoma of skin
0.010 GeneticVariation BEFREE MAPK pathway hyperactivation (through Braf(V600E) or Kras(G12D) knockin) and TGFβ signalling ablation (through Tgfbr1 deletion) in LGR5(+ve) stem cells enables rapid cSCC development in the mouse. 27558455 2016
dbSNP: rs17109924
rs17109924
Entrez Id: 8549
Gene Symbol: LGR5
LGR5
CUI: C0699790
Disease:
Colon Carcinoma
0.010 GeneticVariation BEFREE We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for TTR in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy. 25665511 2015
dbSNP: rs17109924
rs17109924
Entrez Id: 8549
Gene Symbol: LGR5
LGR5
CUI: C0007102
Disease:
Malignant tumor of colon
0.010 GeneticVariation BEFREE We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for TTR in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy. 25665511 2015