IRS2, insulin receptor substrate 2, 8660

N. diseases: 152; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs754205
rs754205
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs754205
rs754205
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs754205
rs754205
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0427460
Disease:
Red cell distribution width determination
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs754205
rs754205
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0206161
Disease:
Reticulocyte count (procedure)
C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs137852740
rs137852740
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C4016690
Disease:
DIABETES, TYPE II, SUSCEPTIBILITY TO
C 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C4016690
Disease:
DIABETES, TYPE II, SUSCEPTIBILITY TO
T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The risk of T2DM in individuals with GG genotype for Gly1057Asp in IRS2 gene was 1.42 times higher than that with AA genotype (OR = 1.422; 95% CI = 1.037-1.949; P = 0.029). 28049237 2017
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association. 25959789 2015
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group. 22994406 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The G1057D polymorphism in the insulin receptor substrate-2 (IRS-2) gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes. 20184486 2010
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These results strongly argue against a major role of the Gly1057Asp IRS-2 polymorphism in the pathogenesis of type 2 diabetes in Djerbian subjects. 19332049 2009
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The G1057D polymorphism of IRS-2 gene and its relationship with obesity in conferring susceptibility to type 2 diabetes in Asian Indians. 16652127 2007
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes. 15811564 2005
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study. 15127203 2004
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The effect of the Gly1057Asp mutation on type 2 diabetes and obesity was tested in a large cohort of Pima Indians (n = 998). 12765968 2003
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy). 12519871 2003
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes. 12213887 2002
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These data provide evidence for a strong association between type 2 diabetes and the G1057D common genetic variant of IRS-2, which appears to be protective against type 2 diabetes in a codominant fashion. 11030756 2000
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity. 27098445 2016
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE We found significant difference in the genotypic distribution of IRS-2 gene Gly1057Asp between the PCOS group and the control group (p = 0.004). 25310961 2014
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE No statistically significant differences in the prevalence of IRS-1 Gly972Arg or IRS-2 Gly1057Asp polymorphisms or any combination of both were observed between controls and PCOS patients (P > 0.02). 22205343 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. 21801267 2011
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE The present study was undertaken to determine whether IRS-1 Gly972Arg and IRS-2 Gly1057Asp influence hormonal and metabolic characteristics in Greek patients with polycystic ovary syndrome (PCOS) and controls. 20210696 2010
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE The Gly972Arg in IRS-1 and Gly1057Asp in IRS-2 polymorphisms influence glucose homeostasis in premenopausal women, but are not associated with PCOS. 16037106 2005
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0032460
Disease:
Polycystic Ovary Syndrome
0.080 GeneticVariation BEFREE These results suggest that the IRS-2 Gly(1057)Asp polymorphism influences blood glucose levels in nondiabetic white and African-American women with PCOS. 12213887 2002