Disease: Leukopenia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs186364861
rs186364861
Entrez Id: 8803;55270
Gene Symbol: SUCLA2;NUDT15
SUCLA2;NUDT15
CUI: C0023530
Disease:
Leukopenia 		0.030 GeneticVariation BEFREE A significantly higher thiopurine-induced leukopenia risk was found for TPMT (OR 3.9, 95% [CI] 2.5-6.1) and for NUDT15 R139C (OR 6.9, 95% CI 5.2-9.1), G52A (OR 3.2, 95% CI 1.3-7.9) and 36_37ins/delGGAGTC variant carriers (OR 5.6, 95% CI 2.8-11.4). 31342537 2019
dbSNP: rs186364861
rs186364861
Entrez Id: 8803;55270
Gene Symbol: SUCLA2;NUDT15
SUCLA2;NUDT15
CUI: C0023530
Disease:
Leukopenia 		0.030 GeneticVariation BEFREE Subgroup analysis for rs186364861 and rs554405994 revealed a significant DOR for early-onset leukopenia (rs186364861: 4.04, 95% CI 1.78-9.20; rs554405994: 2.94, 95% CI 1.74-4.95), but not for late-onset leukopenia (rs186364861: 1.52, 95% CI 0.52-4.43; rs554405994: 2.02, 95% CI 0.93-4.40). 30048756 2018
dbSNP: rs186364861
rs186364861
Entrez Id: 8803;55270
Gene Symbol: SUCLA2;NUDT15
SUCLA2;NUDT15
CUI: C0023530
Disease:
Leukopenia 		0.030 GeneticVariation BEFREE We confirmed that NUDT15 c.415C>T, c.36_37insGGAGTC, and c.52G>A variants were risk factors for thiopurine-induced leukopenia. 28570428 2017