IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1512409
Disease:
Hepatocarcinogenesis
0.010 GeneticVariation BEFREE These findings suggest that ST2 rs3821204 CC genotype may contribute to hepatocarcinogenesis by enhancing ST2 production at the transcriptional and translational level. 29656959 2019
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE The ST2 rs3821204 CC genotype was associated with a significantly increased risk of HCC (CC vs. GG: adjusted OR = 2.29, 95% CI, 1.39-3.78; dominant model: adjusted OR = 1.58, 95% CI, 1.12-2.23; recessive model: adjusted OR = 1.88, 95% CI, 1.21-2.93; C vs. G: adjusted OR = 1.53, 95% CI, 1.20-1.95). 29656959 2019
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1332986
Disease:
Childhood Osteosarcoma
0.010 GeneticVariation BEFREE These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL-33 or ST2. 29797504 2018
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0029463
Disease:
Osteosarcoma
0.010 GeneticVariation BEFREE These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL-33 or ST2. 29797504 2018
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0585442
Disease:
Osteosarcoma of bone
0.010 GeneticVariation BEFREE These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL-33 or ST2. 29797504 2018
dbSNP: rs11685424
rs11685424
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0085580
Disease:
Essential Hypertension
0.010 GeneticVariation BEFREE Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly associated with an increase in risk of EH, while rs6543116 is associated with a decrease risk of EH. 28121058 2017
dbSNP: rs3821204
rs3821204
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0085580
Disease:
Essential Hypertension
0.010 GeneticVariation BEFREE Taken together, our findings provide the first evidence that genetic variants in ST2 gene are associated with EH risk and variant rs3821204 may influence the development of EH by controlling sST2 expression. 28121058 2017
dbSNP: rs6543115
rs6543115
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0009324
Disease:
Ulcerative Colitis
0.010 GeneticVariation BEFREE Our data indicate that IL1RL1 SNPs rs6543115(C) confer susceptibility to UC an</span>d is contained in the GRE, which may modulate glucocorticoid-induced sST2 expression. 28860510 2017
dbSNP: rs6543116
rs6543116
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0009324
Disease:
Ulcerative Colitis
0.010 GeneticVariation BEFREE Sequencing of a distal IL1RL1 promoter region demonstrated that SNPs rs6543115(C) and rs6543116(A) are associated with increased sST2 in UC patients on corticosteroids. 28860510 2017
dbSNP: rs6543116
rs6543116
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0085580
Disease:
Essential Hypertension
0.010 GeneticVariation BEFREE Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly associated with an increase in risk of EH, while rs6543116 is associated with a decrease risk of EH. 28121058 2017
dbSNP: rs950880
rs950880
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1704436
Disease:
Peripheral Arterial Diseases
0.010 GeneticVariation BEFREE The rs950880 AA homozygote is an independent predictor of all-cause mortality in CAD and PAD patients. 28110258 2017
dbSNP: rs950880
rs950880
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE The rs950880 AA homozygote is an independent predictor of all-cause mortality in CAD and PAD patients. 28110258 2017
dbSNP: rs6543116
rs6543116
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0677607
Disease:
Hashimoto Disease
0.010 GeneticVariation BEFREE The frequencies of allele A and AA+AG genotype of rs6543116 (ST2) in HT patients were significantly increased compared with those of the controls (P = 0.029/0.021, OR = 1.31/1.62). 26566691 2016
dbSNP: rs17639215
rs17639215
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0043144
Disease:
Wheezing
0.010 GeneticVariation BEFREE Of the remaining 15 SNPs, for seven we found significant relationships between genotype and endotoxin exposure in the genetic association study in relation to symptomatic airway hyper-responsiveness (CD14-rs2915863 and rs2569191, TRIF-rs4807000), current wheeze (ST-2-rs17639215, IKK-1-rs2230804, and TRIF-rs4807000), and atopy (CD14-rs2915863 and rs2569192, TRAF-6-rs5030411, and IKK-1-rs2230804). 25102764 2014
dbSNP: rs11685424
rs11685424
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE One tag SNP in each gene was significantly associated with CAD (rs7025417(T) in IL33, padj = 1.19 × 10(-28), OR = 1.39, 95% CI: 1.31-1.47; rs11685424(G) in IL1RL1, padj = 6.93 × 10(-30), OR = 1.40, 95% CI: 1.32-1.48). 24075188 2013
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010068
Disease:
Coronary heart disease
0.010 GeneticVariation BEFREE For the other SNPs (rs12619285, rs1420101, and rs4143832), we combined our case-control data with the previous studies and found no association of them with the risk of CHD. 23328882 2013
dbSNP: rs201256810
rs201256810
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901 2013
dbSNP: rs201256810
rs201256810
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0085129
Disease:
Bronchial Hyperreactivity
0.010 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901 2013
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0006271
Disease:
Bronchiolitis
0.010 GeneticVariation BEFREE We studied the association between RSV and 3 selected IL1RL1 single-nucleotide polymorphisms rs1921622, rs11685480 or rs1420101 in 81 ventilated and 384 non-ventilated children under 1 year of age hospitalized with primary RSV bronchiolitis in comparison to 930 healthy controls. 22574108 2012
dbSNP: rs1921622
rs1921622
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0006271
Disease:
Bronchiolitis
0.010 GeneticVariation BEFREE We found a genetic link between rs1921622 IL1RL1 polymorphism and disease severity in RSV bronchiolitis. 22574108 2012
dbSNP: rs1041973
rs1041973
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90). 21281963 2011
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1306759
Disease:
Eosinophilic disorder
0.010 GeneticVariation BEFREE We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF. 19860791 2010
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0014457
Disease:
Eosinophilia
0.010 GeneticVariation BEFREE We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF. 19860791 2010
dbSNP: rs10204137
rs10204137
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010278
Disease:
Craniosynostosis
0.010 GeneticVariation BEFREE Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03). 19671251 2009
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010278
Disease:
Craniosynostosis
0.010 GeneticVariation BEFREE Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03). 19671251 2009