IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0200638
Disease:
Eosinophil count procedure 		A 0.800 GeneticVariation GWASCAT Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610 2009
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0200638
Disease:
Eosinophil count procedure 		A 0.800 GeneticVariation GWASDB Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610 2009
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		T 0.710 GeneticVariation GWASCAT Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. 30578877 2019
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0027430
Disease:
Nasal Polyps 		T 0.710 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		T 0.710 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation BEFREE Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).<i>IL1RL1</i> asthma-risk SNPs strongly associated with <i>IL1RL1</i> methylation (rs1420101; p=3.7×10<sup>-16</sup>) and serum IL1RL1-a levels (p=2.8×10<sup>-56</sup>). 29519908 2018
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0027430
Disease:
Nasal Polyps 		0.710 GeneticVariation BEFREE Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP. 19860791 2010
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010068
Disease:
Coronary heart disease 		0.010 GeneticVariation BEFREE For the other SNPs (rs12619285, rs1420101, and rs4143832), we combined our case-control data with the previous studies and found no association of them with the risk of CHD. 23328882 2013
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0006271
Disease:
Bronchiolitis 		0.010 GeneticVariation BEFREE We studied the association between RSV and 3 selected IL1RL1 single-nucleotide polymorphisms rs1921622, rs11685480 or rs1420101 in 81 ventilated and 384 non-ventilated children under 1 year of age hospitalized with primary RSV bronchiolitis in comparison to 930 healthy controls. 22574108 2012
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1306759
Disease:
Eosinophilic disorder 		0.010 GeneticVariation BEFREE We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF. 19860791 2010
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0014457
Disease:
Eosinophilia 		0.010 GeneticVariation BEFREE We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF. 19860791 2010