NRXN1, neurexin 1, 9378

N. diseases: 20; N. variants: 26
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1356888
rs1356888
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0023980
Disease:
Longevity 		0.800 GeneticVariation GWASCAT Joint influence of small-effect genetic variants on human longevity. 20834067 2010
dbSNP: rs1356888
rs1356888
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0023980
Disease:
Longevity 		0.800 GeneticVariation GWASDB Joint influence of small-effect genetic variants on human longevity. 20834067 2010
dbSNP: rs10490175
rs10490175
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0021704
Disease:
Intelligence 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
dbSNP: rs10490175
rs10490175
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease:
Schizophrenia 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
dbSNP: rs2059308
rs2059308
Entrez Id: 9378;101927089
Gene Symbol: NRXN1;LOC101927089
NRXN1;LOC101927089
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2139629
rs2139629
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs930295
rs930295
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs9636391
rs9636391
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs9636391
rs9636391
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12476120
rs12476120
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0021704
Disease:
Intelligence 		T 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. 29942086 2018
dbSNP: rs141864436
rs141864436
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C3894553
Disease:
response to simvastatin 		0.700 GeneticVariation GWASCAT Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. 28736931 2018
dbSNP: rs141864436
rs141864436
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 GeneticVariation GWASCAT Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. 28736931 2018
dbSNP: rs41522849
rs41522849
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs41522849
rs41522849
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs6545155
rs6545155
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0871470
Disease:
Systolic Pressure 		T 0.700 GeneticVariation GWASCAT Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 30224653 2018
dbSNP: rs6750228
rs6750228
Entrez Id: 9378;730100
Gene Symbol: NRXN1;LOC730100
NRXN1;LOC730100
CUI: C0001925
Disease:
Albuminuria 		A 0.700 GeneticVariation GWASCAT Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. 30220432 2018
dbSNP: rs7557525
rs7557525
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0021704
Disease:
Intelligence 		T 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. 29942086 2018
dbSNP: rs7603103
rs7603103
Entrez Id: 9378;730100
Gene Symbol: NRXN1;LOC730100
NRXN1;LOC730100
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs10174398
rs10174398
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1305855
Disease:
Body mass index 		C 0.700 GeneticVariation GWASCAT Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. 28892062 2017
dbSNP: rs1014667
rs1014667
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1519383
Disease:
Smoking Behaviors 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs1014667
rs1014667
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0037369
Disease:
Smoking 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs115249811
rs115249811
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C3548479
Disease:
response to bronchodilator 		C 0.700 GeneticVariation GWASCAT A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. 26634245 2015
dbSNP: rs1476850082
rs1476850082
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C3280479
Disease:
PITT-HOPKINS-LIKE SYNDROME 2 		G 0.700 GeneticVariation CLINVAR Fraternal twins with autism, severe cognitive deficit, and epilepsy: diagnostic role of chromosomal microarray analysis. 25149956 2014
dbSNP: rs771759988
rs771759988
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C3280479
Disease:
PITT-HOPKINS-LIKE SYNDROME 2 		T 0.700 GeneticVariation CLINVAR Fraternal twins with autism, severe cognitive deficit, and epilepsy: diagnostic role of chromosomal microarray analysis. 25149956 2014
dbSNP: rs11681792
rs11681792
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT A genome-wide association study of behavioral disinhibition. 23942779 2013