rs2300747
CD58;MIR548AC
Multiple Sclerosis
0.820
GeneticVariation
BEFREE
The goal of the current study was to investigate the association of single nucleotide polymorphisms (SNP) with the immunologically related genes responsible for the disease, composed of CD58 (rs2300747 A>G), CD226 (rs763361 C>T), and HLA-G (rs1611715 A>C), with MS susceptibility.
30128676 2018
rs2300747
CD58;MIR548AC
Multiple Sclerosis
0.820
GeneticVariation
GWASCAT
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
27386562 2016
rs2300747
CD58;MIR548AC
Multiple Sclerosis
0.820
GeneticVariation
GWASDB
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088 2011
rs2300747
CD58;MIR548AC
Multiple Sclerosis
A
0.820
GeneticVariation
GWASCAT
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
22190364 2011
rs2300747
CD58;MIR548AC
Multiple Sclerosis
A
0.820
GeneticVariation
GWASDB
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
22190364 2011
rs2300747
CD58;MIR548AC
Multiple Sclerosis
A
0.820
GeneticVariation
GWASCAT
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953 2009
rs2300747
CD58;MIR548AC
Multiple Sclerosis
0.820
GeneticVariation
BEFREE
This protective rs2300747 (G) allele is associated with a dose-dependent increase in CD58 mR NA expression in lymphoblastic cell lines (P = 1.1 x 10(-10)) and in peripheral blood mononuclear cells from MS </span >subjects (P = 0.0037).
19237575 2009
rs2300747
CD58;MIR548AC
Multiple Sclerosis
A
0.820
GeneticVariation
GWASDB
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953 2009
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
0.810
GeneticVariation
BEFREE
In summary, our results suggest that ASCL2 mediates the protective function of rs1335532 minor (C) allele in MS .
30006149 2018
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.810
GeneticVariation
GWASDB
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
24234648 2014
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.810
GeneticVariation
GWASDB
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088 2011
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.810
GeneticVariation
GWASCAT
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088 2011
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
0.810
GeneticVariation
GWASDB
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
22190364 2011
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.810
GeneticVariation
GWASDB
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
19525955 2009
rs1335532
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.810
GeneticVariation
GWASCAT
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
19525955 2009
rs2300747
CD58;MIR548AC
Primary biliary cirrhosis
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.
28425483 2017
rs6677309
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Multiple Sclerosis
A
0.700
GeneticVariation
GWASCAT
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
24076602 2013
rs2300747
CD58;MIR548AC
Neuromyelitis Optica
0.020
GeneticVariation
BEFREE
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747 , rs1335532, rs56302466, rs1016140, and rs12044852).
28601281 2017
rs2300747
CD58;MIR548AC
Neuromyelitis Optica
0.020
GeneticVariation
BEFREE
Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk.
24655566 2014
rs12044852
CD58;LOC105378925
Neuromyelitis Optica
0.010
GeneticVariation
BEFREE
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852 ).
28601281 2017
rs56302466
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Neuromyelitis Optica
0.010
GeneticVariation
BEFREE
In conclusion, this study identified a new NMOSD susceptibility variant, rs56302466 , and suggested that CD58 polymorphisms are associated with the risk of NMOSD in Han Chinese.
28601281 2017
rs1414273
CD58;MIR548AC
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
Sequencing data of the 1000 Genomes project revealed a SNP, rs1414273 , at the base of the microRNA stem-loop to be in strong linkage disequilibrium with the MS -associated haplotype.
25795118 2015
rs1016140
×
Entrez Id: 965
Gene Symbol: CD58
CD58
Neuromyelitis Optica
0.010
GeneticVariation
BEFREE
Also, we deduced that the G allele of rs1016140 caused an increase of T cell activity, which in turn eased the access of AQP4 antibody into central nervous system (CNS) and ultimately leading to NMO development.
24655566 2014
rs12044852
CD58;LOC105378925
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6.
22411505 2012