HDAC4, histone deacetylase 4, 9759

N. diseases: 256; N. variants: 9
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2048765
rs2048765
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0428886
Disease:
Mean blood pressure 		A 0.700 GeneticVariation GWASCAT Interethnic analyses of blood pressure loci in populations of East Asian and European descent. 30487518 2018
dbSNP: rs2048765
rs2048765
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Interethnic analyses of blood pressure loci in populations of East Asian and European descent. 30487518 2018
dbSNP: rs2048765
rs2048765
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0428886
Disease:
Mean blood pressure 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs55875066
rs55875066
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0153535
Disease:
Malignant melanoma of skin of upper limb 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs55875066
rs55875066
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0151779
Disease:
Cutaneous Melanoma 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs55875066
rs55875066
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0153536
Disease:
Malignant melanoma of skin of lower limb 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs2100172
rs2100172
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs9308908
rs9308908
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs9308908
rs9308908
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs370963321
rs370963321
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE We discovered three HDAC4 mutations (p.His227Arg, p.Asp234Asn, and p.Glu374Lys) in unrelated individuals who had nonautoimmune diabetes with various degrees of β-cell loss. 30968599 2019
dbSNP: rs370963321
rs370963321
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0011847
Disease:
Diabetes 		0.010 GeneticVariation BEFREE We discovered three HDAC4 mutations (p.His227Arg, p.Asp234Asn, and p.Glu374Lys) in unrelated individuals who had nonautoimmune diabetes with various degrees of β-cell loss. 30968599 2019
dbSNP: rs61754648
rs61754648
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0013473
Disease:
Eating Disorders 		0.010 GeneticVariation BEFREE In a family affected by eating disorders, a missense mutation in HDAC4 (A786T) was found to segregate with the illness. 30742020 2019
dbSNP: rs62182100
rs62182100
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C1263846
Disease:
Attention deficit hyperactivity disorder 		0.010 GeneticVariation BEFREE A bootstrapping mediation analysis demonstrated that the selective attention variability factor mediated the relationship between rs62182100 and self-reported ADHD symptoms. 30287865 2018
dbSNP: rs73000144
rs73000144
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0600139
Disease:
Prostate carcinoma 		0.010 GeneticVariation BEFREE The HDAC4 (2q37.2) variant rs73000144 (OR = 14.6, p = 0.018) and the EFCAB13 (17q21.3) variant rs118004742 (OR = 1.8, p = 0.048) were overrepresented in patients with familial PrCa. 25335771 2015
dbSNP: rs73000144
rs73000144
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE The HDAC4 (2q37.2) variant rs73000144 (OR = 14.6, p = 0.018) and the EFCAB13 (17q21.3) variant rs118004742 (OR = 1.8, p = 0.048) were overrepresented in patients with familial PrCa. 25335771 2015
dbSNP: rs1063639
rs1063639
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE In the present study, rs1063639 of the HDAC4 gene showed associations with schizophrenia in the codominant and dominant models. 20471694 2010