rs10033464, None

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status. 24910551 2014
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Common single nucleotide polymorphisms at chromosome 4q25 (rs2200733, rs10033464) are associated with both lone and typical atrial fibrillation (AF). 23178686 2013
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001). 22818067 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In multivariable analysis, the presence of any common single nucleotide polymorphism (rs2200733, rs10033464) at the 4q25 locus was an independent predictor of AF recurrence (hazard ratio 2.1; 95% confidence interval 1.21-3.30; P = .008). 23428961 2013
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE This SNP (rs10033464) was an independent predictor of AF recurrence in the discovery (39% AF recurrence) and validation (38% AF recurrence) cohorts; OR: 3.27, 95% CI: 1.7 to 6, p < 0.001 and OR: 4.3, 95% CI: 1.98 to 9.4, p < 0.001, respectively. 22726630 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. 18991354 2008
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3). 29624624 2018
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent. 19141561 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. 31393025 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF). 25684755 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence. 31169720 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively). 21414601 2011
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF. 27346453 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence. 29240960 2018
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Variants conferring risk of atrial fibrillation on chromosome 4q25. 17603472 2007
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASDB Variants conferring risk of atrial fibrillation on chromosome 4q25. 17603472 2007