rs10033464, None

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status. 24910551 2014
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Common single nucleotide polymorphisms at chromosome 4q25 (rs2200733, rs10033464) are associated with both lone and typical atrial fibrillation (AF). 23178686 2013
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001). 22818067 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In multivariable analysis, the presence of any common single nucleotide polymorphism (rs2200733, rs10033464) at the 4q25 locus was an independent predictor of AF recurrence (hazard ratio 2.1; 95% confidence interval 1.21-3.30; P = .008). 23428961 2013
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE This SNP (rs10033464) was an independent predictor of AF recurrence in the discovery (39% AF recurrence) and validation (38% AF recurrence) cohorts; OR: 3.27, 95% CI: 1.7 to 6, p < 0.001 and OR: 4.3, 95% CI: 1.98 to 9.4, p < 0.001, respectively. 22726630 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. 18991354 2008
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3). 29624624 2018
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent. 19141561 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. 31393025 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASDB Variants conferring risk of atrial fibrillation on chromosome 4q25. 17603472 2007
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF). 25684755 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Variants conferring risk of atrial fibrillation on chromosome 4q25. 17603472 2007
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence. 31169720 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively). 21414601 2011
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF. 27346453 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence. 29240960 2018
Ischemic stroke
CUI: C0948008
Disease: Ischemic stroke
0.030 GeneticVariation BEFREE Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke.However, the results are inconsistent. 26162320 2016
Ischemic stroke
CUI: C0948008
Disease: Ischemic stroke
0.030 GeneticVariation BEFREE We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. 18991354 2008
Ischemic stroke
CUI: C0948008
Disease: Ischemic stroke
0.030 GeneticVariation BEFREE The rs10033464 variant failed to show any relationship with ischemic stroke. 20671249 2010
Paroxysmal atrial fibrillation
CUI: C0235480
Disease: Paroxysmal atrial fibrillation
0.010 GeneticVariation BEFREE The combination of plasma TIMP-1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. 31393025 2019
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.010 GeneticVariation BEFREE Multiple clinical variables (including age, hypertension, lone AF) failed to significantly predict response to AADs; however, single nucleotide polymorphism (SNP) rs10033464 at 4q25 was an independent predictor of successful rhythm control in patients with typical AF carrying the ancestral allele (wild type) versus carriers of variant allele (odds ratio [OR]: 4.7, 95% confidence interval [CI]: 1.83 to 12, p = 0.0013. 22726630 2012
Cat eye syndrome
CUI: C0265493
Disease: Cat eye syndrome
0.010 GeneticVariation BEFREE We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. 18991354 2008
Cardioembolic stroke
CUI: C1531624
Disease: Cardioembolic stroke
0.010 GeneticVariation BEFREE Subsequently subgroup analysis indicated that both rs2200733 and rs10033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology. 24065534 2013
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.010 GeneticVariation BEFREE Subsequently subgroup analysis indicated that both rs2200733 and rs1</span>0033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology. 24065534 2013
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.010 GeneticVariation BEFREE Two hundred and sixty-seven individuals comprising of 170 patients with Coronary Artery Disease (CAD), 41 patients with AF, and 56 healthy controls were genotyped for rs10033464 and rs2200733 at 4q25 locus. 27346453 2017