Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status.
|
24910551 |
2014 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms at chromosome 4q25 (rs2200733, rs10033464) are associated with both lone and typical atrial fibrillation (AF).
|
23178686 |
2013 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001).
|
22818067 |
2012 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In multivariable analysis, the presence of any common single nucleotide polymorphism (rs2200733, rs10033464) at the 4q25 locus was an independent predictor of AF recurrence (hazard ratio 2.1; 95% confidence interval 1.21-3.30; P = .008).
|
23428961 |
2013 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
This SNP (rs10033464) was an independent predictor of AF recurrence in the discovery (39% AF recurrence) and validation (38% AF recurrence) cohorts; OR: 3.27, 95% CI: 1.7 to 6, p < 0.001 and OR: 4.3, 95% CI: 1.98 to 9.4, p < 0.001, respectively.
|
22726630 |
2012 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3).
|
29624624 |
2018 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF.
|
31393025 |
2019 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASDB |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
|
31169720 |
2019 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively).
|
21414601 |
2011 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF.
|
27346453 |
2017 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence.
|
29240960 |
2018 |
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke.However, the results are inconsistent.
|
26162320 |
2016 |
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs10033464 variant failed to show any relationship with ischemic stroke.
|
20671249 |
2010 |
Paroxysmal atrial fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
The combination of plasma TIMP-1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF.
|
31393025 |
2019 |
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multiple clinical variables (including age, hypertension, lone AF) failed to significantly predict response to AADs; however, single nucleotide polymorphism (SNP) rs10033464 at 4q25 was an independent predictor of successful rhythm control in patients with typical AF carrying the ancestral allele (wild type) versus carriers of variant allele (odds ratio [OR]: 4.7, 95% confidence interval [CI]: 1.83 to 12, p = 0.0013.
|
22726630 |
2012 |
Cat eye syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
Cardioembolic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently subgroup analysis indicated that both rs2200733 and rs10033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology.
|
24065534 |
2013 |
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently subgroup analysis indicated that both rs2200733 and rs1</span>0033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology.
|
24065534 |
2013 |
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two hundred and sixty-seven individuals comprising of 170 patients with Coronary Artery Disease (CAD), 41 patients with AF, and 56 healthy controls were genotyped for rs10033464 and rs2200733 at 4q25 locus.
|
27346453 |
2017 |