Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C risk variant rs1006737 affects cortical white matter integrity in schizophrenia.
|
25470093 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits.
|
22957138 |
2012 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
|
25588813 |
2015 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have reported an association between the A-allele of rs1006737 within CACNA1C and affective disorders and schizophrenia.
|
22665259 |
2013 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nine teams, including four European decent samples and five Asian samples, contributed 14,141 cases and 30,679 controls for the analysis of CACNA1C rs1006737 and SZ.
|
26227746 |
2015 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results provide further support for associations of rs1006737</span> and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations.
|
24355530 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis of the haplotype rs1006737-rs4765905-rs882194 in CACNA1C showed significant associations with schizophrenia (corrected global p<0.005), and two haplotypes (ACC and ACT) in the block were significantly increased in the patients.
|
24275578 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients.
|
30607529 |
2019 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
|
31033230 |
2019 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP).
|
22012475 |
2012 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we have used our UK case samples of recurrent major depression (N=1196) and schizophrenia (N=479) and UK non-psychiatric comparison groups (N=15316) to examine the spectrum of phenotypic effect of the bipolar risk allele at rs1006737.
|
19621016 |
2010 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ.
|
26049408 |
2015 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia.
|
25290268 |
2014 |
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |