|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We combined genotyping of SNP rs1006737 in CACNA1C with structural MRI measurements of relative gray matter (GM) amygdala volume in patients with SZ, BD or OCD as well as healthy controls (N Total = 72).
|
23880959 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity.
|
25976633 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC)).
|
28398341 |
2017 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using three samples, including healthy controls, patients with SCZ, and patients currently in manic episodes of BP, this study tested the association between the SNP rs1006737 and spatial working memory as measured by an N-back task and a dot pattern expectancy (DPX) task.
|
22012475 |
2012 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
Mental disorders
|
|
0.750 |
GeneticVariation
|
BEFREE |
Our study is the first to provide evidence for an impairing behavioral effect of the CACNA1C risk variant rs1006737 on facial emotion recognition in healthy individuals and adds to the growing number of studies pointing towards CACNA1C as affecting intermediate phenotypes of psychiatric disorders.
|
26611642 |
2015 |
|
Mental disorders
|
|
0.750 |
GeneticVariation
|
BEFREE |
The rs1006737 (A/G) single nucleotide polymorphism within the gene encoding the Ca<sub>v</sub>1.2 subunit of the L-type voltage-dependent calcium channel (CACNA1C) has been strongly implicated in psychiatric disorders.
|
29733866 |
2018 |
|
Mental disorders
|
|
0.750 |
GeneticVariation
|
BEFREE |
These studies demonstrate that the risk genotype at rs1006737 is associated with significant functional alterations in human iNs, and may direct future efforts at developing novel therapeutics for the treatment of psychiatric disease.
|
25403839 |
2015 |
|
Mental disorders
|
|
0.750 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified the CACNA1C single nucleotide polymorphism (SNP) rs1006737 as one of the most consistent genetic findings as susceptibility locus for major psychiatric disorders.
|
24269271 |
2014 |
|
Mental disorders
|
|
0.750 |
GeneticVariation
|
BEFREE |
Several genome-wide association studies and case-control studies have associated the single nucleotide polymorphism (SNP) rs1006737, situated in CACNA1C encoding the alpha 1C subunit of the L-type voltage-gated calcium channel, with bipolar disorder and other psychiatric disorders.
|
26541689 |
2016 |
|
Psychotic Disorders
|
|
0.730 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Psychotic Disorders
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
Psychotic Disorders
|
|
0.730 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Unipolar Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
|
Abnormal behavior
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study is the first to provide evidence for an impairing behavioral effect of the CACNA1C risk variant rs1006737 on facial emotion recognition in healthy individuals and adds to the growing number of studies pointing towards CACNA1C as affecting intermediate phenotypes of psychiatric disorders.
|
26611642 |
2015 |
|
Mood Disorders
|
|
0.040 |
GeneticVariation
|
BEFREE |
Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia as well as mood disorders.
|
22957138 |
2012 |