|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association.
|
27260792 |
2016 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The current data provide further evidence for an impact of rs1006737 on the left IFG and demonstrate that genetic variation in CACNA1C modulates neural responses in patients with MDD.
|
24612926 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
|
20351715 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
|
20351715 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |