rs10069690, TERT

N. diseases: 53
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation BEFREE The variants rs10069690 and rs2853676 were also described as risk factors for BC. 29332343 2019
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. 29058716 2017
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation BEFREE This meta-analysis suggested that TERT rs2736109, rs2853669, rs2736098, and rs10069690 polymorphisms were associated with increased risk of developing breast cancer. 27461695 2017
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation BEFREE Different genotypes of rs3803662 (TOX3)/ (TNRC9)) in the case group and the control group are statistically significant (P = 0.044), but the ones of rs10069690 (TERT), rs2046210 (6q25.1), rs2981582 (EGFR2), and rs889312 (MAP3K1) have no significant statistical differences with breast cancer (P = 0.772, 0.308, 0.376, 0.468). 26803517 2016
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 25751625 2015
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 23535729 2013
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation BEFREE Several TL-related single nucleotide polymorphisms had modest association with breast cancer risk overall, including TEP1 rs93886 (OR 0.82, 95% CI 0.70,0.95); TERF2 rs3785074 (OR 1.13, 95% CI 1.03,1.24); TERT rs4246742 (OR 0.85, 95% CI 0.77,0.93); TERT rs10069690 (OR 1.13, 95% CI 1.03,1.24); TERT rs2242652 (OR 1.51, 95% CI 1.11,2.04); and TNKS rs6990300 (OR 0.89, 95% CI 0.81,0.97). 23629941 2013
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733 2013
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation BEFREE Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2). 23593120 2013
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.750 GeneticVariation GWASCAT We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). 22037553 2011