rs10069690, TERT

N. diseases: 53
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of ovary
CUI: C1140680
Disease: Malignant neoplasm of ovary
0.020 GeneticVariation BEFREE A splicing variant in TERT, rs10069690, showed a statistically significant interaction with ET use for risk of serous ovarian cancer (p<sub>int</sub>  = 0.013). 27420401 2016
Malignant neoplasm of ovary
CUI: C1140680
Disease: Malignant neoplasm of ovary
0.020 GeneticVariation BEFREE The minor allele (A) at rs10069690 creates an additional splice donor site in intron 4 of hTERT, and is associated with an elevated risk of multiple cancers including breast and ovarian carcinomas. 26053551 2015