|
Hepatitis C, Chronic
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
|
21725309 |
2011 |
|
Hepatitis C, Chronic
|
|
0.800 |
GeneticVariation
|
GWASDB |
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
|
21725309 |
2011 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
After controlling for the influence of sex, smoking and drinking, this study showed a significant relationship between the polymorphism of DEPDC5 rs1012068 and HBV-related HCC.
|
30683632 |
2019 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
There was a significant correlation between DEPDC5 rs1012068A/C and HBV-related HCC in the Han Chinese population.
|
30683632 |
2019 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150).
|
26517016 |
2016 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Rs423058 upstream of PAPL, rs2834167 in IL10RB and rs1012068 in DEPDC5 were associated with chronic HBV status, HBV natural clearance and the presence of HCC (P = 0.0004–0.024), respectively.
|
25032264 |
2014 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
BEFREE |
The data also revealed that subjects with the T allele of both SNPs appeared to have a lower susceptibility to HCV-related cirrhosis/HCC than those with the G allele of rs1012068 (p = 0.038, OR = 1.353, 95 % CI 1.017-1.800) and C allele of rs5998152 (p = 0.043, OR = 1.342, 95 % CI 1.010-1.784).
|
25551790 |
2014 |
|
Liver carcinoma
|
|
0.760 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, DEPDC5 rs1012068 was independently associated with cirrhosis (n = 300; P = 0.049).
|
26517016 |
2016 |
|
Liver Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, DEPDC5 rs1012068 was independently associated with cirrhosis (n = 300; P = 0.049).
|
26517016 |
2016 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection.
|
26517016 |
2016 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, multiple logistic regression analysis showed that rs5998152 (OR = 2.844, 95% CI 1.333-6.069 and p = 0.007), rs1012068 (OR = 2.793, 95% CI 1.316-5.928 and p = 0.010), age (OR = 1.029, 95% CI 1.001-1.057 and p = 0.041) and HCV genotypes (OR = 0.247, 95% CI 0.097-0.630 and p = 0.003) were independently associated with chronicity of HCV infection.
|
25551790 |
2014 |
|
Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p = 0.0104) and CT for SNP rs5998152 (OR = 1.932; 95% CI 1.276-2.925; p = 0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively.
|
25551790 |
2014 |
|
Liver Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p = 0.0104) and CT for SNP rs5998152 (OR = 1.932; 9</span>5% CI 1.276-2.925; p = 0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively.
|
25551790 |
2014 |