rs10423928, GIPR

N. diseases: 12
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
Glucose tolerance test
CUI: C0017741
Disease: Glucose tolerance test
0.800 GeneticVariation GWASDB Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
Glucose tolerance test
CUI: C0017741
Disease: Glucose tolerance test
0.800 GeneticVariation GWASCAT Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Systolic Pressure
CUI: C0871470
Disease: Systolic Pressure
0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
Blood urea nitrogen measurement
CUI: C0005845
Disease: Blood urea nitrogen measurement
0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. 26395740 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Our objective was to examine the interactions between rs10423928 and macronutrients and fiber intakes on body mass index and type 2 diabetes risk. 22399504 2012
Heart failure
CUI: C0018801
Disease: Heart failure
0.010 GeneticVariation BEFREE From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018). 31209632 2019
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.010 GeneticVariation BEFREE From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018). 31209632 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.010 GeneticVariation BEFREE SNPs rs7607980 near COBLL1 (p = 0.0001), rs13389219 near GRB14 (p = 0.026) and rs10423928 in the GIPR gene (p = 0.012) as well as the genetic risk score (GRS) for these previously shown insulin resistance loci here associated with insulin resistance defined by HOMA2-IR and showed a trend towards GDM. 30089489 2018
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.010 GeneticVariation BEFREE Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. 26395740 2016
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.010 GeneticVariation BEFREE Body mass index change for the A/T+A/A genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. 25321336 2015
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.010 GeneticVariation BEFREE Our findings suggest that schizophrenic patients with the A allele of GIPR rs10423928 are at risk of developing hyperinsulinemia when treated with antipsychotics. 21747410 2012