|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs1042522 was also selected as a CM risk factor in multivariate models, suggesting an effect that is independent from and complementary to that of rs1805007.
|
31612033 |
2019 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Risk of cancer specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered.
|
28336930 |
2017 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that genotypes for the TP53 rs1042522 G>C polymorphism might not be associated with the risk of melanoma.
|
26148609 |
2016 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.
|
25774791 |
2015 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The data suggest for the first time that P53 Arg72Pro, MDM2 c.+309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms, enrolled in apoptosis pathways, constitute distinct determinants of CM in women and men.
|
24461648 |
2014 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports.
|
22336942 |
2012 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro.
|
19318491 |
2009 |
|
melanoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the association of the Arg72Pro polymorphism with skin cancer risk among Caucasians in a nested case-control study within the Nurses' Health Study (NHS) (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) and 874 controls).
|
16739124 |
2006 |