Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association between p53 Arg72Pro polymorphism and colorectal cancer risk in Asian population: a meta-analysis. 30316510 2018
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. 29872345 2018
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population. 28554075 2017
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies. 27901479 2017
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study. 25537146 2015
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population. 22393962 2011
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. 21051533 2011
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We did not identify an association between TP53 rs1042522 and colorectal cancer. 20615891 2010
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population. 20449797 2010
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. 18988302 2008
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers. 17599946 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients. 17224235 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use. 17622940 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45). 16721787 2006
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53. 16353134 2006