|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis demonstrated that C79G and C491T polymorphism may be a defensive factor for asthma, while A46G polymorphism may be a risk factor for asthma among the Caucasian population.
|
31115019 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the rs1042713 polymorphism, no significant association with asthma risk was found in the overall population.
|
31699066 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the clinical value of ADRB2 rs1042713 in children with asthma using LABA, a randomized clinical trial with well-defined outcomes is needed.
|
29992699 |
2018 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma.
|
27385593 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The primary objective was to determine the association between beta-2 adrenergic receptor (ADRB2) gene polymorphism (rs1042713, c.46A>G, p.Arg16Gly) and the response to inhaled salbutamol in North Indian children aged 5 to 15 years, with mild to moderate exacerbation of asthma.
|
27029682 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05).
|
26613553 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prospective genotype-stratified clinical trials are now required to explore the potential role of rs104</span>2713 genotyping for personalized asthma therapy in children.
|
26774659 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.
|
26071206 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
|
26505596 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma.
|
25985706 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Chinese Han children with asthma</span> had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group.
|
24838642 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population.
|
24992184 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach.
|
23205695 |
2013 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with β2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans.
|
23384627 |
2013 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant outcome was that all variant alleles at the SNP loci were part of the haplotype conferring resistance to malaria disease and asthma, except rs1042713 and rs1042718 which showed very high frequency in asthma.
|
24012958 |
2013 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use.
|
22883364 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).
|
22075484 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the group of mestizo schoolchildren studied, the Arg16Gly and Gln27Glu polymorphisms are not markers of susceptibility or severity of asthma and do not affect ADRB2 gene expression during the rescue therapy.
|
22328447 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism, and to test whether LABA or inhaled corticosteroid (ICS) use modified these effects.
|
21436355 |
2011 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Early studies suggest that bronchodilator reversibility and asthma worsening in patients on continuous short-acting and long-acting beta-agonists are related to the Gly16Arg genotype for the ADRB2.
|
19077707 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of this study were: (1) to find associations of asthma with single-nucleotide polymorphisms (SNPs) within the ADRB2 gene: Arg16Gly, Gln27Glu, -1023 G/A, -367 T/C, -47 C/T ; (2) to define linkage disequilibrium in the gene region, basing on the analyzed SNPs; and (3) to analyze the importance of ADRB2 polymorphism for response to bronchodilator drugs in children diagnosed with bronchial asthma.
|
19638684 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Eleven single nucleotide polymorphisms (SNPs) in CHRM1-3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding beta(2) adrenoreceptor) were scored in 80 of the 138 asthmatics.
|
19183167 |
2009 |