rs1042713, ADRB2

N. diseases: 63
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene. 30468638 2019
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE The present meta-analysis demonstrated that C79G and C491T polymorphism may be a defensive factor for asthma, while A46G polymorphism may be a risk factor for asthma among the Caucasian population. 31115019 2019
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE For the rs1042713 polymorphism, no significant association with asthma risk was found in the overall population. 31699066 2019
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE To assess the clinical value of ADRB2 rs1042713 in children with asthma using LABA, a randomized clinical trial with well-defined outcomes is needed. 29992699 2018
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future. 30178312 2018
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME. 28294290 2017
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma. 27385593 2016
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE The primary objective was to determine the association between beta-2 adrenergic receptor (ADRB2) gene polymorphism (rs1042713, c.46A>G, p.Arg16Gly) and the response to inhaled salbutamol in North Indian children aged 5 to 15 years, with mild to moderate exacerbation of asthma. 27029682 2016
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05). 26613553 2016
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE Prospective genotype-stratified clinical trials are now required to explore the potential role of rs104</span>2713 genotyping for personalized asthma therapy in children. 26774659 2016
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics. 26071206 2015
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.100 GeneticVariation BEFREE Each analysis consistently revealed the 46A allele of ADRB2 46G/A SNP and 4a allele of NOS3 4b/4a SNP to be associated with risk of hypertension. 25159081 2015
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response. 26505596 2015
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma. 25985706 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated. 24960039 2014
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE The Chinese Han children with asthma</span> had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group. 24838642 2014
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE This meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population. 24992184 2014
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach. 23205695 2013
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with β2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans. 23384627 2013
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE A significant outcome was that all variant alleles at the SNP loci were part of the haplotype conferring resistance to malaria disease and asthma, except rs1042713 and rs1042718 which showed very high frequency in asthma. 24012958 2013
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.100 GeneticVariation BEFREE CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension. 22731644 2012
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use. 22883364 2012
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.100 GeneticVariation BEFREE The results indicated that 46A/G polymorphism in the β2-AR gene was associated with hypertension susceptibility in Han Chinese population. 22763735 2012
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05). 22731644 2012
Asthma
CUI: C0004096
Disease: Asthma
0.100 GeneticVariation BEFREE We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD). 22075484 2012