rs1042718, ADRB2

N. diseases: 3
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.020 GeneticVariation BEFREE The ADRB2 rs1042718 alleles had a 1.29-fold (95%CI = 1.00-1.66; p = 0.045) increased risk of HAPE, and the GSTP1 rs749174 alleles had a 0.71-fold (95%CI = 0.52-0.99; p = 0.042) decreased risk of HAPE. 28212552 2017
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.020 GeneticVariation BEFREE The MDR model depicted SNP 46A/G, 79C/G and 523C/A as the best combination predicting disease. conclusions: The haplotypes of ADRB2 consisting of the SNP, 46A/G and 79C/G, have a greater power for predicting HAPE. 20546540 2010
Fatigue
CUI: C0015672
Disease: Fatigue
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787 2017
Asthma
CUI: C0004096
Disease: Asthma
0.010 GeneticVariation BEFREE A significant outcome was that all variant alleles at the SNP loci were part of the haplotype conferring resistance to malaria disease and asthma, except rs1042713 and rs1042718 which showed very high frequency in asthma. 24012958 2013