|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whether the C3435T polymorphism can act as a marker for the natural history of treated epilepsy remains to be determined.
|
15857428 |
2005 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and eight patients with drug-responsive epilepsy, 63 patients with drug-resistant epilepsy, and 219 control migraine subjects were studied, but the analysis for C3435T allele showed no significant association between the CC genotype and the multidrug-resistant epilepsy.
|
16542858 |
2006 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 T-129C, C1236T, G2677T/A and C3435T polymorphisms were genotyped in 210 Japanese epileptics who had been prescribed AEDs, including CBZ, for longer than 2 years.
|
16753003 |
2006 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association.
|
16857572 |
2006 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that C3435T is unlikely to be a marker for epilepsy multidrug resistance.
|
17460550 |
2007 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
For a single gene test, it was demonstrated that 3435C>T in the ABCB1 gene had a significant effect on epilepsy treatment responses, but polymorphisms in the NR1I2 gene did not.
|
17924830 |
2007 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.
|
18436433 |
2008 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic drugs.
|
19167193 |
2009 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We included all published studies until September 2007, in which patients with responsive and unresponsive seizure disorders underwent genotyping for ABCB1 C3435T.
|
19178561 |
2009 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, the authors investigated the association between the MDR1 gene polymorphisms, C3435T and G2677AT, and drug resistance epilepsy by using polymerase chain reaction/restriction fragment length polymorphism and pyrosequencing methods in a group of 39 patients with drug-resistant epilepsy and 92 controls.
|
20448249 |
2010 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34).
|
20491876 |
2010 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We failed to show an association between the ABCB1 C3435T polymorphism and the risk of drug-resistance suggesting a revision in contribution of this polymorphism in the multi-drug transporters hypothesis of pharmacoresistance to AEDs in epilepsy.
|
20605481 |
2010 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
|
21388909 |
2011 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population.
|
21420937 |
2011 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the ABCB1 rs3789243 C>T, C1236T, G2677T/A, rs6949448 C>T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
|
21530324 |
2011 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
|
23984379 |
2013 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy.
|
24213830 |
2014 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We suggest that the influence of the C3435T polymorphism in predicting the drug-resistance in epilepsy, might be significant and further investigations focusing on carbamazepine and phenytoin, in various ethnic populations are necessary to clarify the effect of C3435T polymorphism on the multidrug resistance in epilepsy patients.
|
24300029 |
2014 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a significant association was observed between ABCB1 (C3435T) rs1045642 and risk of having epilepsy (MTLE-HS and JME pooled cohort; genotypic p-value = 0.0002; allelic p-value = 0.004).
|
24586633 |
2014 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was conducted to assess the role of the C3435T polymorphism in drug-resistance in epilepsy.
|
24794827 |
2014 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
|
25223475 |
2014 |